Table 5

Impact of the number of patient changes in each individual study on bias

Number of studies=5	Control group probability=0.001		Group ratio=1		OR=0.5		Number of simulated data sets=2500				Between-study SD=0.5
	Excluding BA0E studies						Including BA0E studies
	n=50		n=100		n=250		n=50		n=100		n=250
Methods		%bias		%bias		%bias		%bias		%bias		%bias
IV random effects	0.73	−45.7	0.70	−40.6	0.68	−36.5	0.98	−96.8	0.97	−70.7	0.93	−86.0
IV fixed effects	0.73	−45.8	0.70	−40.6	0.68	−36.3	0.98	−96.5	0.96	−68.5	0.92	−84.5
M-H random effects	0.73	−45.7	0.70	−40.6	0.68	−36.5	0.98	−96.8	0.97	−70.7	0.93	−86.0
M-H fixed effects	0.73	−45.8	0.70	−40.6	0.68	−36.3	0.98	−96.5	0.96	−68.5	0.92	−84.5
Peto	0.58	−15.2	0.54	−7.8	0.51	−2.4	0.98	−95.8	0.95	−59.5	0.90	−80.7