Number of studies=5 | Control group probability=0.001 | Group ratio=1 | OR=0.5 | Number of simulated data sets=2500 | Between-study SD=0.5 | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|

Excluding BA0E studies | Including BA0E studies | |||||||||||

n=50 | n=100 | n=250 | n=50 | n=100 | n=250 | |||||||

Methods | %bias | %bias | %bias | %bias | %bias | %bias | ||||||

IV random effects | 0.73 | −45.7 | 0.70 | −40.6 | 0.68 | −36.5 | 0.98 | −96.8 | 0.97 | −70.7 | 0.93 | −86.0 |

IV fixed effects | 0.73 | −45.8 | 0.70 | −40.6 | 0.68 | −36.3 | 0.98 | −96.5 | 0.96 | −68.5 | 0.92 | −84.5 |

M-H random effects | 0.73 | −45.7 | 0.70 | −40.6 | 0.68 | −36.5 | 0.98 | −96.8 | 0.97 | −70.7 | 0.93 | −86.0 |

M-H fixed effects | 0.73 | −45.8 | 0.70 | −40.6 | 0.68 | −36.3 | 0.98 | −96.5 | 0.96 | −68.5 | 0.92 | −84.5 |

Peto | 0.58 | −15.2 | 0.54 | −7.8 | 0.51 | −2.4 | 0.98 | −95.8 | 0.95 | −59.5 | 0.90 | −80.7 |

BA0E, both-armed zero-event; IV, inverse variance; M-H, Mantel-Haenszel.