Table 1

Preclinical study characteristics

ID	Publication	Drug	Species	n	Dose (duration)	Motor score	Injury level	Follow-up	Type of injury	Application
1	Redondo-Castro, E	Ibu	Rats	16	60 mg/kg/day (42 days)	BBB	T8	42 days	Contusion	Subcutaneous
2	Sharp, K	Ibu	Rats	73	60 mg/kg/day (28 days)	BBB	T6/7	42 days	Hemisection	Subcutaneous
3	Wang, X	Ibu	Mice	46	35–70 mg/kg/day (28 days)	BMS	T8	35 days	Transection	Subcutaneous
4	Guth, L	Indo	Rats	12	0.2 mg/day (21 days)	Tarlov	T8	21 days	Compression	Intraperitoneal
5	Wang, X	Ibu	Rats	47	70 mg/kg/day (28 days)	BBB	T7	49 days	Contusion	Subcutaneous
6 7	Fu, Q	Ibu	Rats	19 12	60 mg/kg/day (28 days) 60 mg/kg/day (28 days)	BBB	T6/7	42 days	Hemisection	Subcutaneous
6 7	Fu, Q	Ibu	Rats	19 12	60 mg/kg/day (28 days) 60 mg/kg/day (28 days)	BBB	T6/7	42 days	Contusion	Subcutaneous
8 9 10 11	Pantovic, R	Indo	Rabbits	6 6 6 6 6	0.1 mg/kg/day (9 days) 0.3 mg/kg/day (9 days) 1.0 mg/kg/day (9 days) 3.0 mg/kg/day (9 days) vehicle	Tarlov	L2	9 days	Contusion	Intravenous

BBB, Basso, Beattie and Bresnahan; BMS, Basso Mouse Scale; Ibu, ibuprofen; Indo, indometacin; n, number of animals.