Table 3

Outcome MAI

	Intervention group			Control group
MAI sum score at patient level	n_i	M_i (SD)	Median_i (IQR)	n_c	M_c (SD)	Median_c (IQR)	ICC/ICC_adj	p Value
T0	50	5.0 (4.69)	3.5 (2–6.75)	50	4.8 (5.40)	3 (1–6.75)	0.085/0.099	0.882
T1	48	5.1 (5.12)	4 (1–7.25)	48	4.2 (5.09)	2 (0–7)	0.000/0.000	0.401
T2	46	5.7 (6.57)	3 (1–7)	47	4.6 (4.76)	3 (1–7)	0.049/0.053	0.387
MAI sum score T1-T0	48	0.1 (5.31)	0.5 (−3–3)	48	−0.6 (5.56)	0 (−2.25–1.25)	0.023/0.032	0.548
M_I-M_C (95% CI), not adjusted						−0.7 (−1.6 to 0.2)*
M_I-M_C (95% CI), adjusted for clustering						−0.7 (−3.0 to 1.6)*
MAI sum score T2-T0	46	0.7 (5.45)	0 (−2–3)	47	−0.2 (5.17)	0 (−2–2.5)	0.030/0.039	0.460
M_I-M_C (95% CI), not adjusted						−0.9 (−1.8 to 0.1)*
M_I-M_C (95% CI), adjusted for clustering						−0.9 (−3.2 to 1.4)*
Inappropriate prescriptions per group		Numbern_i/N_i	Proportion%		Numbern_c/N_c	Proportions%
T0		130/439	29.6		108/412	26.2
T1		109/415	26.3		90/385	23.4
T2		107/393	27.2		99/371	26.7
Inappropriate prescriptions per patient		NumberM_i (SD)	ProportionM_i (SD)		NumberM_c (SD)	ProportionM_c (SD)
T0		2.60 (1.67)	0.30 (0.18)		2.16 (1.80)	0.25 (0.19)
T1		2.27 (1.82)	0.26 (0.20)		1.875 (1.81)	0.22 (0.20)
T2		2.33 (1.89)	0.26 (0.20)		2.11 (1.82)	0.24 (0.20)

If not stated otherwise, mean (M) and SD are provided. ICCs are provided as crude values and adjusted for group. p Values are adjusted for cluster effects.
*The trend was in favour of the control group.
ICC, intracluster correlation coefficient; MAI, medication appropriateness index.