Table 3

Schedule of evaluations for the PHACS AMP Up study

Assessment	Data collection method	Study visit
Assessment	Data collection method	Entry (in-clinic)	Year 1	Year 2	Year 3 (in-clinic)	Year 4	Year 5	Year 6 (in-clinic)
Demographic and psychosocial factors
Education, employment, housing	Online survey	√	√	√	√	√	√	√
Healthcare usage, transition to adult clinical care	Online survey	√	√	√	√	√	√	√
Social support, friendships, self-efficacy	Online evaluation	√			√			√
Quality of life	Online survey	√	√	√	√	√	√	√
Physical activity	Online evaluation	√			√			√
Nutrition	Online survey		√	√	√	√	√	√
Medical and neuropsychological factors
Diagnoses*	Chart abstraction	√	√	√	√	√	√	√
Medications	Chart abstraction	√	√	√	√	√	√	√
Height, weight, blood pressure*	Chart abstraction	√	√	√	√	√	√	√
Body measurements	Clinic visit	√			√			√
Reproductive health	Online survey	√	√	√	√	√	√	√
Neurocognitive functioning	Online evaluation	√			√			√
Mental health: depression screen	Interview	√			√			√
Mental health: psychiatric diagnoses	Interview				√			√
Hearing	Online evaluation	√			√			√
Language	Interview	√
Laboratories done for clinical care	Chart abstraction	√	√	√	√	√	√	√
Laboratory biomarkers†	Clinic visit	√			√			√
Sexually transmitted infections	Self-collection	√	√	√	√	√	√	√
Repository samples‡	Clinic visit	√			√			√
Behavioural factors
Sexual behaviour	Online survey	√	√	√	√	√	√	√
Substance use	Online survey	√	√	√	√	√	√	√
ART adherence	Online survey	√	√	√	√	√	√	√

*Pregnancies, fractures, hearing problems, height and weight are also self-reported in annual online surveys.
†Venous lactate/pyruvate, renal biomarkers, cardiac biomarkers, fasting lipids, glucose, insulin.
‡Serum and plasma (EDTA and heparin), PBMC, throat wash/gargle, saliva, urine, vaginal swab.
AMP, Adolescent Master Protocol; EDTA, ethylenediamine tetraacetic acid; PBMC, peripheral blood mononuclear cells; PHACS, Pediatric HIV/AIDS Cohort Study.