Table 1

Variables used in the original prognostic models—prognostic variables included in the final models (only type 1 prognostic models presented) and points assigned (in numbers) to each variable when applied. Rule stands for scoring rule, score for simplified scoring rule or scoring system

Models		GPS	No acronym (Polish model)	PESI	PE Prognostic Algorithm	No acronym (Spanish model)	No acronym (Dutch model)	EMEP	No acronym (Japanese model)	No acronym (Chinese model)	Simplified PESI	PREP	UPS	No acronym	Simple Score FAST	SIRS-WCC	No acronym	eStiMaTe (PROTECT)
Model construction studies (derivation samples)		(Wicki et al122)	(Kostrubiec et al90)	(Aujesky et al68)	(Aujesky et al69)	(Uresandi et al118)	(Agterof et al67)	(Volschan et al121)	(Yamaki et al123)	(Zhu et al124)	(Jimenez et al85)	(Sanchez et al110)	(Agterof et al65)	(Huang et al129)	(Lankeit et al92) and (Dellas et al80)	(Jo et al89)	(Bova et al135)	(Jiménez et al87)
N of candidate variables		14	NR	29	29	>30	7	20	16	NR	11	>30	7	38	NR	NR	Unclear	13
N of variables in final model		6	2	11	10	7	2	5	7	8	6	5	4	4	3	4	4	4
Proposed risk assessment method		Score	Rule	Score	Rule	Score	Rule	Score	Score	Equation	Score	Score	Rule	Score	Score	None	Score	Calculator
Type of selected variables in final model	Total N*
Demographic and clinical characteristics
Age	6			Age, in year	x	1		3			1							x
Gender (male sex)	2			10					2
Syncope	2									x					1.5
Leg symptoms	1								1
Immobilisation/bed rest	2					2		2
No recent surgery	1					1
Active cancer	8	2		30	x				2		1	6	x					x
Metastatic cancer	1					4
Non-metastatic cancer	1					2
Previous DVT/PE	2	1							2
Heart failure	3	1		10	x
Chronic lung disease	3			10	x									x
Chronic cor pulmonale	1							4
Heart failure or chronic lung disease	2										1							x
Chronic renal disease	1				x
Cerebrovascular disease	1				x
Recent bleeding	1					4
Inadequate anticoagulation	1								1
Clinical findings
Cardiogenic shock	2											6				x
HR	12			20	x		x	2		x	1		x	x	2	x	1	x
SBP	6	2		30	x						1						2	x
RR	3			20				2								x
Temperature	2			20												x
Altered mental status	4			60	x							10				x
PaO₂/SpO₂	5	1		20	x						1							x
Accentuation of P2	1									x
Laboratory findings
WCC	3									x				x		x
Creatinine	1					3
CPK	1									x
cTnI	1																	x
cTnT	1		x
hscTn	0
cTn	1																2
BNP	1											x						x
NT-proBNP	2		x										x
D-dimer	3						x						x	x
H-FABP	1														1.5
Imaging findings
US-DVT	3	1							1									x
US-proximal DVT	1								1
TTE-RVD	1									x
TTE-RV/LV ratio	2									x		x
TTE-SPAP	1									x
CT-RVD	1															x
RVD (TTE or CT)	1																2

*Total N is the number of times a variable has been included across studies.
BNP, brain natriuretic peptide; CK, creatine kinase; cTnI, cardiac troponin I; cTnT, cardiac troponin T; DVT, deep vein thrombosis; EMEP, Estudo Multicêntrico de Embolia Pulmonar; GPS, Geneva prognostic score; H-FABP, heart-type fatty acid-binding protein; hscTnT, high-sensitive cardiac troponin; NR, not reported; NT-proBNP, N-terminal proBNP; PE, pulmonary embolism; PESI, PE Severity Index; PREP, Facteurs PRonostiques dans l'Embolie Pulmonaire; RR, relative risk; RVD, right ventricular dysfunction; SBP, systolic blood pressure; SIRS-WCC, systemic inflammatory response system—WCC; SPAP, systolic pulmonary artery pressure; TTE, transthoracic echocardiography; UPS, Utrecht Prediction Score; US-DVT, ultrasound-detected DVT; WCC, white cell count.