Table 1

Summary of findings for study-level meta-analysis of parenteral anticoagulants in cancer

Estimated absolute effects at 1 year
Outcome†Relative effect (95% CI)Without LMWH (per 1000)With LMWH (per 1000)Difference (per 1000)Certainty of the effect
DeathRR 0.94 (0.88 to 1.00)50147130 fewer deaths (60 to 0 fewer)⊕⊕○
Moderate due to imprecision
Symptomatic venous thromboembolismRR 0.57 (0.40 to 0.81)462620 fewer events (9 to 27 fewer)⊕⊕⊕⊕
High
Major bleedingRR 1.06 (0.71 to 1.57)16171 more major bleed (from 5 fewer to 9 more)⊕⊕⊕○
Moderate due to imprecision
Minor bleedingRR 1.18 (0.89 to 1.55)27325 more minor bleeds (from 3 fewer to 15 more)⊕⊕⊕⊕
High
  • CVC, central venous catheter; LMWH, low-molecular weight heparin; PE, pulmonary embolism.