Summary of findings for study-level meta-analysis of parenteral anticoagulants in cancer
| Estimated absolute effects at 1 year | |||||
|---|---|---|---|---|---|
| Outcome† | Relative effect (95% CI) | Without LMWH (per 1000) | With LMWH (per 1000) | Difference (per 1000) | Certainty of the effect |
| Death | RR 0.94 (0.88 to 1.00) | 501 | 471 | 30 fewer deaths (60 to 0 fewer) | ⊕⊕○ Moderate due to imprecision |
| Symptomatic venous thromboembolism | RR 0.57 (0.40 to 0.81) | 46 | 26 | 20 fewer events (9 to 27 fewer) | ⊕⊕⊕⊕ High |
| Major bleeding | RR 1.06 (0.71 to 1.57) | 16 | 17 | 1 more major bleed (from 5 fewer to 9 more) | ⊕⊕⊕○ Moderate due to imprecision |
| Minor bleeding | RR 1.18 (0.89 to 1.55) | 27 | 32 | 5 more minor bleeds (from 3 fewer to 15 more) | ⊕⊕⊕⊕ High |
CVC, central venous catheter; LMWH, low-molecular weight heparin; PE, pulmonary embolism.