In-hospital, 30-day and 3-month all-cause mortality, and distribution of risk groups for relevant risk cut-offs
| Outcome time point | Prognostic model Cut-off—risk groups | Prevalence of risk groups N (%) (95% CI) | Incidence of events within risk groups N (%) (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Derivation | Internal validation | External validation | Overall | Derivation | Internal validation | External validation | Overall | ||
| In-hospital mortality | GPS-3 | 1 | 1 | ||||||
| High | (18.9) (14.1 to 24.9) | 7.9 (2.6 to 21.8) | |||||||
| Low | (81.1) (75.1 to 85.9) | 0.6 (0.1 to 4.2) | |||||||
| PESI-III | 1 | 1 | 3 | 5 | 1 | 1 | 3 | 5 | |
| High | (59.1) (58.1 to 60) | (59.3) (57.9 to 60.6) | (55.8) (41 to 69.7) | (58.4) (55.1 to 61.6) | (8.8) (8.1 to 9.5) | (9.8) (8.8 to 10.9) | (9.8) (6.5 to 14.4) | (9.3) (8.4 to 10.4) | |
| Low | (40.9) (40 to 41.9) | (40.7) (39.4 to 42.1) | (44.2) (30.3 to 59) | (41.6) (38.4 to 44.9) | (1.3) (1 to 1.7) | (1.5) (1.1 to 2.1) | (2.2) (1 to 4.7) | (1.4) (1.2 to 1.8) | |
| sPESI | 2 | 2 | |||||||
| High | (53.9) (29.2 to 76.8) | (3.2) (1.6 to 6.4) | |||||||
| Low | (46.1) (23.2 to 70.8) | (0.3) (0 to 2.3) | |||||||
| Algorithm | 1 | 1 | 2 | 4 | 1 | 1 | 2 | 4 | |
| High | (78.4) (77.6 to 79.2) | (78.4) (77.3 to 79.5) | (76.1) (55.1 to 89.2) | (78) (75.1 to 80.7) | (5.2) (4.7 to 5.7) | (6.1) (5.4 to 6.9) | (3.6) (0.7 to 16.2) | (5.8) (4.8 to 7) | |
| Low | (21.6) (20.8 to 22.4) | (21.6) (20.5 to 22.7) | (23.9) (10.8 to 44.9) | (22) (19.3 to 24.9) | (0.4) (0.2 to 0.8) | (0.9) (0.5 to 1.7) | (0.6) (0.1 to 3.1) | (0.6) (0.4 to 1) | |
| ESC | 3 | 3 | |||||||
| High | (10.2) (3.3 to 27.3) | (41.1) (22.7 to 62.5) | |||||||
| Low | (89.8) (72.7 to 96.7) | (5) (3.6 to 7.1) | |||||||
| Shock Index | 1 | 1 | |||||||
| High | (17.4) (12.2 to 24.2) | (22.2) (10.3 to 41.4) | |||||||
| Low | (82.6) (75.8 to 87.8) | (3.9) (1.6 to 9) | |||||||
| 30-day mortality | GPS-3 | 1 | 1 | ||||||
| High | (18) (14.1 to 22.7) | (20.1) (11.4 to 33) | |||||||
| Low | (82) (77.3 to 85.9) | (9.8) (3.2 to 26.6) | |||||||
| PESI-III | 1 | 1 | 7 | 9 | 1 | 1 | 7 | 9 | |
| High | (59.1) (58.1 to 60) | (59.3) (57.9 to 60.6) | (56.1) (48.6 to 63.3) | (56.9) (53.4 to 60.4) | (14) (13.1 to 14.9) | (14.2) (13.1 to 15.5) | (9.8) (8.0 to 11.9) | (11.4) (9.9 to 13.1) | |
| Low | (40.9) (40 to 41.9) | (40.7) (39.4 to 42.1) | (43.9) (36.7 to 51.4) | (43.1) (39.6 to 46.6) | (2.1) (1.8 to 2.6) | (2.6) (2 to 3.3) | (1.8) (1.0 to 3.2) | (2.3) (1.7 to 2.9) | |
| sPESI | 1 | 10 | 11 | 1 | 10 | 11 | |||
| High | (69.3) (66.4 to 72.1) | (63.1) (59.8 to 66.3) | (63.7) (60.6 to 66.7) | (10.9) (8.8 to 13.4) | (10.6) (8.6 to 13) | (10.7) (8.8 to 12.9) | |||
| Low | (30.7) (27.9 to 33.6) | (36.9) (33.7 to 40.2) | (36.3) (33.3 to 39.4) | (1) (0.3 to 3) | (1.6) (0.9 to 2.7) | (1.5) (0.9 to 2.5) | |||
| PREP Clin—II | 1 | 1 | |||||||
| High | (32.8) (27.7 to 38.3) | (7.1) (3.4 to 14.1) | |||||||
| Low | (67.2) (61.7 to 72.3) | (1) (0.2 to 3.9) | |||||||
| Algorithm | 1 | 1 | 2 | 4 | 1 | 1 | 2 | 4 | |
| High | (78.4) (77.6 to 79.2) | (78.4) (77.3 to 79.5) | (76.1) (55.1 to 89.2) | (78) (75.1 to 80.7) | (11.5) (10.8 to 12.2) | (11.7) (10.7 to 12.7) | (7.9) (2.5 to 22.4) | (11.6) (10.4 to 12.9) | |
| Low | (21.6) (20.8 to 22.4) | (21.6) (20.5 to 22.7) | (23.9) (10.8 to 44.9) | (22) (19.3 to 24.9) | (0.6) (0.3 to 1) | (1.5) (0.9 to 2.4) | (1.6) (0.6 to 4.5) | (1.1) (0.5 to 2.1) | |
| ESC | 1 | 1 | |||||||
| High | (10.1) (8 to 12.6) | (26.5) (16.1 to 40.4) | |||||||
| Low | (89.9) (87.4 to 92) | (8.9) (4.7 to 16.5) | |||||||
| Shock Index | 2 | 2 | |||||||
| High | (19.7) (11.3 to 32) | (24.1) (13.6 to 39.1) | |||||||
| Low | (80.3) (68 to 88.7) | (10.7) (6.1 to 17.9) | |||||||
| 3-month mortality | GPS-3 | 2 | 2 | ||||||
| High | (18) (14.1 to 22.7) | 23.6 (14.2 to 36.6) | |||||||
| Low | (82) (77.3 to 85.9) | 4.9 (2.8 to 8.4) | |||||||
| PESI-III | 6 | 6 | |||||||
| High | (49.6) (43.3 to 56.0) | (13.0) (8.7 to 18.9) | |||||||
| Low | (50.4) (44.0 to 56.7) | (1) (0.5 to 1.8) | |||||||
| sPESI | 3 | 3 | |||||||
| High | (53.8) (39.4 to 67.6) | (13.6) (8.8 to 20.3) | |||||||
| Low | (46.2) (32.4 to 60.6) | (0.8) (0.3 to 2.2) | |||||||
| PREP Clin=II | 1 | 1 | |||||||
| High | (32.8) (27.7 to 38.3) | (9.1) (4.8 to 16.6) | |||||||
| Low | (67.2) (61.7 to 72.3) | (1.5) (0.5 to 4.5) | |||||||
ESC, European Society of Cardiology; GPS, Geneva prognostic score; N, number of studies; PESI, Pulmonary Embolism Severity Index; PREP, Facteurs PRonostiques dans l'Embolie Pulmonaire; sPESI, simplified PESI.