TableĀ 3

Absolute sensitivity of hrHPV testing on cervical, vaginal and urine samples and cytology to detect CIN2+ or CIN3+

TestOutcomeSensitivity(95% CI)Specificity(95% CI)
Cervical hrHPVCIN2+, n=13097.7%95.0% to 100.0%87.3%86.4% to 88.2%
Vaginal hrHPV94.6%90.7% to 98.5%85.4%84.4% to 86.3%
Urine hrHPV63.1%54.6% to 71.7%89.8%89.0% to 90.7%
Cervical LBC (borderl+)75.4%68.0% to 82.8%96.9%96.4% to 97.3%
Cervical hrHPVCIN3+, n=6898.6%95.9% to 100.0%86.4%85.5% to 87.3%
Vaginal hrHPV95.8%91.1% to 100.0%84.8%83.8% to 85.8%
Urine hrHPV50.7%39.1% to 62.3%89.7%88.8% to 90.5%
Cervical LBC (borderl+)76.1%66.1% to 86.0%96.1%95.5% to 96.6%
  • CIN, cervical intraepithelial neoplasia; hrHPV, high-risk human papillomavirus; LBC, liquid-based cytology.