Table 2

Drug dosing schedule

Renal functionColistin maintenance dose*Meropenem dosing
CrCl ≥50 mL/min†4.5 MIU q12 h2 g q8 h
CrCl <50 mL/min, without renal replacement therapyTotal daily dose in MIU=(2×(1.5×CrCl+30))/30CrCl 26–50 mL/min: 2 g q12 hCrCl 10–25 mL/min: 1 g q12 h
Continuous renal replacement therapyFixed dose of 6 MIU q12 h1 g q12 h
Intermittent haemodialysis1 MIU q12 h, with a 1 MIU supplemental dose after dialysis1 g q24 h with a supplemental dose given after dialysis
  • *All patients receive a loading dose of 9 MIU regardless of renal function. Adjustment refers only to the maintenance dose started 12 h after the loading dose.

  • †CrCl should be expressed in mL/min/1.73 m2, using the modification of diet in renal disease (MDRD) formula, Cockcroft and Gault equation or other means.