Table 1

Trial design, visits and end points

Variable	Baseline	12 months	24 months	60 months
Sex	X
Age	X
Height	X
Current smoker	X	X¹	X²	X³
Tender joints	X	X¹	X²	X³
Swollen joints	X	X¹	X²	X³
IgM-RF	X
Anti-CCP	X			X⁴
C reactive protein	X	X¹	X²	X³
Patient global	X	X¹	X²	X³
Patient pain	X	X¹	X²	X³
Patient fatigue	X	X¹	X²	X³
LDL cholesterol	X	X¹	X²	X³
HDL cholesterol	X	X¹	X²	X³
Total cholesterol	X	X¹	X²	X³
Triglycerides	X	X¹	X²	X³
Body weight	X	X¹	X²	X³
Blood pressure: systolic	X	X¹	X²	X³
Blood pressure: diastolic	X	X¹	X²	X³
Cardiovascular acute hospitalisation	X	X¹	X²	X³
Cardiovascular disease	X	X¹	X²	X³
CSFQ-14	X	X¹	X²	X³
MDI	X	X¹	X²	X³
SF-12	X	X¹	X²	X³
LI-Sat	X	X¹	X²	X³
Self-reported 15-item questionnaire on sexual activity	X	X¹	X²	X³

Paper 1. Multifactorial intervention and cardiovascular disease in patients with early RA after a 1-year follow-up considering data marked with (1).
Paper 2. Multifactorial intervention and cardiovascular disease in patients with early RA after a 2-year follow-up considering data marked with (2).
Paper 3. Effect of a multifactorial intervention on mortality in patients with RA after 5 years of follow-up considering data marked with (3).
CCP, cyclic citrullinated peptide antibodies; CSFQ, Changes in Sexual Functioning Questionnaires; HDL, high-density lipoprotein; KRAMS, nurse counselling regarding diet, smoking, alcohol use and exercise habits; LDL, low-density lipoprotein; Li-sat, Questions concerning sexual well-being, body image and sexological counselling; MDI, Major Depression Inventory; NSJ, number of swollen joints; NTJ, number of tender joints; RA, rheumatoid arthritis; RF, rheumatoid factor SF-12, short form 12-items health survey.