Table 1

ETAPE study procedure and evaluation criteria

	Selection	Inclusion	M3	M6	M9	M12
Inclusion criteria	×
Informed consent	×
Somatic parameters weight, height, BMI, waist circumference, blood pressure, temperature	–	×	×	×	×	×
Tanner stage	–	×	–	×	–	×
AIMS36
SAS37 38	–	×	×	×	×	×
BARS39
BFCRS40
Laboratory assessment
Full blood count, liver enzymes, creatine phosphokinase, glycaemia, cholesterol (total, HDL, LDL), triglycerides, hsCRP,	–	×	×	×	×	×
Prolactin, insulin, HbA1c, HOMA	–	×	×	×	–	×
Vitamin D	–	×	×	–	–	×
Thyroid hormones	–	×	–	–	–	×
ECG, QTc interval	–	×	–	×	–	×
Semistructured interview K-SADS41 MINI/MINI-kid42	–	×	–	–	–	×
Clinician questionnaires CGI-S43 44	–	×	×	×	×	×
CGAS45 46	–	×	–	×	–	×
PAERS47	–	×	×	×	×	×
Patient Questionnaires
QEWP48	–	×	×	×	×	×
HAQ49 50	–	–	×	×	×	×
SDS51	–	×	×	×	×	×
Dennison52	–	×	×	×	×	×

AIMS, abnormal involuntary movement scale; BARS, barnes akathisia rating scale; BFCRS, bush francis catatonia rating scale; BMI, body mass index; CGAS: clinical global assessment scale; CGI-S, clinical global impression scale; ECG, electrocardiogram; HAQ, helping alliance questionnaire; HDL, high-density lipoprotein; hs-CRP, high sensitivity C-reactive protein; HbA1c, glycated haemoglobin; HOMA, insulin resistance; K-SADS, SAS, simpson and angus scale; LDL, low-density lipoprotein; MINI, mini international neuropsychiatric interview; PAERS, pediatric adverse event rating scale; QEWP, questionnaire of eating and weight patterns; schedule for affective disorders and schizophrenia for school age children; SDS, sheehan disability scale.