Table 1

Outcome measures

Outcome measureMeasurement point (months)
Primary outcome measure
1. MRI analysis0, 12
  • Cartilage volume

  • Cartilage defect grade (grade 0–4)

2. Knee Injury and Osteoarthritis Outcome Score0, 1, 3, 6, 12
Secondary outcome measure
1. MRI analysis0, 12
  • Bone marrow lesion (grade 1–2)

  • Bone area

  • T2 cartilage mapping

2. Numerical Pain Rating scale (0–10)0, 1, 3, 6, 12
3. Patient global impression of change(7-point Likert scale)1, 3, 6, 12
4. Treatment Satisfaction scale (5-point Likert scale)1, 3, 6, 12
5. Pain medication in previous week (yes/no, type and dose)1, 3, 6, 12