Genotype and allele frequencies of GDF1 SNP rs4808863 in controls and subtypes of CHDs
| T vs C | CT vs CC | CT+TT vs CC | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | p Value | OR | 95% CI | p Value | OR | 95% CI | p Value | OR | 95%CI | |
| Controls | 95 | 26 | 3 | – | – | – | – | – | – | – | – | – |
| CTDs | 36 | 19 | 1 | 0.147 | 1.558 | 0.853 to 2.845 | 0.066 | 1.928 | 0.953 to 3.903 | 0.085 | 1.820 | 0.916 to 3.617 |
| AVSD | 5 | 10 | 0 | 0.007* | 3.375 | 1.450 to 7.857 | 0.001* | 7.308 | 2.296 to 23.261 | 0.001* | 6.552 | 2.072 to 20.717 |
| APVR | 3 | 1 | 0 | 1.000* | 0.9964 | 0.209 to 4.442 | 1.000* | 1.218 | 0.122 to 12.201 | 1.000* | 1.092 | 0.109 to 10.903 |
| LVOTO | 7 | 8 | 1 | 0.013* | 3.068 | 1.332 to 7.069 | 0.018* | 4.176 | 1.386 to 12.586 | 0.013* | 4.212 | 1.442 to 12.300 |
| RVOTO | 3 | 3 | 0 | 0.444* | 2.250 | 0.578 to 8.752 | 0.260* | 3.654 | 0.696 to 19.179 | 0.321* | 3.276 | 0.627 to 17.116 |
| Septal | 11 | 5 | 0 | 0.880* | 1.250 | 0.449 to 3.480 | 0.576* | 1.661 | 0.530 to 5.207 | 0.704* | 1.489 | 0.478 to 4.637 |
| Heterotaxy | 2 | 2 | 0 | 0.643* | 2.250 | 0.435 to 11.632 | 0.217* | 3.654 | 0.491 to 27.199 | 0.462* | 3.276 | 0.442 to 24.293 |
| Complex | 4 | 0 | 0 | – | – | – | – | – | – | – | – | – |
*p Value from adjusted χ2 test with continuity correction.
Significant differences between cases and controls are shown in bold.
APVR, anomalous pulmonary venous return; AVSD, atrioventricular septal defects; CHDs, congenital heart defects; CTDs, conotruncal defects; LVOTO, left ventricular outflow tract obstruction; RVOTO, right ventricular outflow tract obstruction; SNPs, single-nucleotide polymorphisms.