Table 5

Genotype and allele frequencies of GDF1 SNP rs4808863 in controls and subtypes of CHDs

 T vs CCT vs CCCT+TT vs CC
CCCTTTp ValueOR95% CIp ValueOR95% CIp ValueOR95%CI
CTDs361910.1471.5580.853 to 2.8450.0661.9280.953 to 3.9030.0851.8200.916 to 3.617
AVSD51000.007*3.3751.450 to 7.8570.001*7.3082.296 to 23.2610.001*6.5522.072 to 20.717
APVR3101.000*0.99640.209 to 4.4421.000*1.2180.122 to 12.2011.000*1.0920.109 to 10.903
LVOTO7810.013*3.0681.332 to 7.0690.018*4.1761.386 to 12.5860.013*4.2121.442 to 12.300
RVOTO3300.444*2.2500.578 to 8.7520.260*3.6540.696 to 19.1790.321*3.2760.627 to 17.116
Septal11500.880*1.2500.449 to 3.4800.576*1.6610.530 to 5.2070.704*1.4890.478 to 4.637
Heterotaxy2200.643*2.2500.435 to 11.6320.217*3.6540.491 to 27.1990.462*3.2760.442 to 24.293
  • *p Value from adjusted χ2 test with continuity correction.

  • Significant differences between cases and controls are shown in bold.

  • APVR, anomalous pulmonary venous return; AVSD, atrioventricular septal defects; CHDs, congenital heart defects; CTDs, conotruncal defects; LVOTO, left ventricular outflow tract obstruction; RVOTO, right ventricular outflow tract obstruction; SNPs, single-nucleotide polymorphisms.