Genotype and allele frequencies of GDF1 SNP rs4808863 in controls and fetuses with CHD
| Genotype/allele frequency | |||||
|---|---|---|---|---|---|
| Genotype/allele | CHDs | Controls | χ2 | p Value | OR (95% CI) |
| CC | 71 | 95 | – | – | – |
| CT | 48 | 26 | 9.994 | 0.002 | 2.47 (1.400 to 4.358) |
| TT | 2 | 3 | 0.015 | 1.000* | 0.892 (0.145 to 5.480) |
| C | 190 | 216 | – | – | – |
| T | 52 | 32 | 6.354 | 0.012 | 1.847 (1.141 to 2.990) |
| CT+TT | 50 | 29 | 9.017 | 0.003 | 2.307 (1.329 to 4.003) |
| CC+CT | 119 | 121 | 0.180 | 1.000* | 1.475 (0.242 to 8.98) |
*p Value from adjusted χ2 tests with continuity correction.
Significant differences between cases and controls are shown in bold.
CC, CT and TT are genotypes of GDF1 SNP rs4808863. C and T are alleles at rs4808863. CT+TT, dominant model; CC+CT, recessive model.
CHDs, congenital heart defects; SNPs, single-nucleotide polymorphisms.