Table 1

Findings from the focused review

Author(s) and details of paperDateClinical area or procedureCountryLevel of studyImpactFindingImprovement identified
By-product papers
 Adler MW. Changes in local clinical practice following an experiment in medical care: evaluation of evaluation. J Epidemiol Community Health 1978;32:143–6. hernia and varicose veinsUKOS+P
 Andersen M, Kragstrup J, Sondergaard J. How conducting a clinical trial affects physicians’ guideline adherence and drug preferences. JAMA 2006;295:2759–64.*2006AsthmaDenmarkOS-P
 Chen AY, Schrag N, Hao Y, Flanders WD, Kepner J, Stewart A, et al. Changes in treatment of advanced laryngeal cancer 1985–2001. Otolaryngol Head Neck Surg 2006;135:831–7. (laryngeal)USOB+P
 Clark WF, Garg AX, Blake PG, Rock GA, Heidenheim AP, Sackett DL. Effect of awareness of a randomized controlled trial on use of experimental therapy. JAMA 2003;290:1351–5. -P
 Das D, Ishaq S, Harrison R, Kosuri K, Harper E, Decaestecker J, et al. Management of Barrett’s esophagus in the UK: overtreated and underbiopsied but improved by the introduction of a national randomised trial. Am J Gastroenterol 2008;103:1079–89.'s oesophagusUKCS+P
 du Bois A, Rochon J, Lamparter C, PFisterer J, and for the Organkommission OVAR. Pattern of care and impact of participation in clinical studies on the outcome in ovarian cancer. Int J Gynecol Cancer 2005;15:183–91*2005Ovarian cancerGermanyOB+HO
 Hébert-Croteau N, Brisson J, Latreille J, Blanchette C, Deschenes L. Variations in the treatment of early-stage breast cancer in Quebec between 1988 and 1994. CMAJ 1999;161:951–51999Breast cancerCanadaOB+P
 Janni W, Kiechle M, Sommer H, Rack B, Gauger K, Heinrigs M, et al. Study participation improves treatment strategies and individual patient care in participating centers. Anticancer Res 2006;26:3661–7. cancerGermanyOS+P
 Jha P, Deboer D, Sykora K, Naylor CD. Characteristics and mortality outcomes of thrombolysis trial participants and nonparticipants: a population-based comparison. J Am Coll Cardiol 1996;27:1335–42.
 Jones B, Ratzer E, Clark J, Zeren F, Haun W. Does peer-reviewed publication change the habits of surgeons? Am J Surg 2000;180:566–9.
 Karjalainen S, Palva I. Do treatment protocols improve end results? A study of survival of patients with multiple myeloma in Finland. BMJ 1989;299:1069–72.
 Kizer JR, Cannon CP, McCabe CH, Mueller HS, Schweiger MJ, Davis VG, et al. Trends in the use of pharmacotherapies for acute myocardial infarction among physicians who design and/or implement randomized trials vs physicians in routine clinical practice: the MILIS-TIMI experience. Multicenter investigation on limitation of infarct size. Am Heart J 1999;137:79–921999AMIUSCB+P
 Majumdar SR, Chang W-C, Armstrong PW. Do the investigative sites that take part in a positive clinical trial translate that evidence into practice? Am J Med 2002;113:140–5.*2002AMICanadaOS-P
 Majumdar SR, Roe MT, Peterson ED, Chen AY, Gibler WB, Armstrong PW. Better outcomes for patients treated at hospitals that participate in clinical trials. Arch Intern Med 2008;168:657–62.*2008Unstable anginaUSOB+HO
 Meineche-Schmidt V, Hvenegaard A, Juhl HH. Participation in a clinical trial influences the future management of patients with gastro-oesophageal reflux disease in general practice. Aliment Pharmacol Ther 2006;24:1117–25.*2006Gastro-oesophageal refluxDenmarkCS+P
 Morton AN, Bradshaw CS, Fairley CK. Changes in the diagnosis and management of bacterial vaginosis following clinical research. Sex Health 2006;3:183–5. healthAustraliaCSM+P
 Pancorbo-Hidalgo PL, Garcia-Fernandez FP, Lopez-Medina IM, Lopez-Ortega J. Pressure ulcer care in Spain: nurses’ knowledge and clinical practice. J Adv Nurs 2007;58:327–38.*2006Pressure ulcerSpainCB+P
 Pons J, Sais C, Illa C, Méndez R, Suñen E, Casas M, et al. Is there an association between the quality of hospitals’ research and their quality of care? J Health Serv Res Policy 2010;15:204–9.*2010AMISpainOB+HO
 Rich AL, Tata LJ, Free CM, Stanley RA, Peake MD, Baldwin DR, et al. How do patient and hospital features influence outcomes in small-cell lung cancer in England? Br J Cancer 2011;105:746–52.*2011Small cell lung cancerUKOBM+P
 Rochon J, du Bois A. Clinical research in epithelial ovarian cancer and patients’ outcome. Ann Oncol 2011;22(Suppl. 7):vii16–19.*2011Ovarian cancerGermanyOB+HO
 Salbach NM, Guilcher SJ, Jaglal SB, Davis DA. Determinants of research use in clinical decision making among physical therapists providing services post-stroke: a cross-sectional study. Implementation Sci 2010;5:77.
Network papers
Abraham AJ, Knudsen HK, Rothrauff TC, Roman PM. The adoption of alcohol pharmacotherapies in the Clinical Trials Network: the influence of research network participation. J Subst Abuse Treat 2010;38:275–83.*2010Alcohol-use disordersUSOB+P
 Carpenter WR, Reeder-Hayes K, Bainbridge J, Meyer A-M, Amos KD, Weiner BJ, et al. The role of organizational affiliations and research networks in the diffusion of breast cancer treatment innovation. Med Care 2011;49:172–9.*2011Breast cancerUSOB+P
 Ducharme LJ, Knudsen HK, Roman PM, Johnson JA. Innovation adoption in substance abuse treatment: exposure, trialability, and the Clinical Trials Network. J Subst Abuse Treat 2007;32:321–9.*2007Substance abuseUSOSM+P
 Knudsen HK, Abraham AJ, Johnson JA, Roman PM. Buprenorphine adoption in the National Drug Abuse Treatment Clinical Trials Network. J Subst Abuse Treat 2009;37:307–12.*2009Substance abuseUSOS+P
 Laliberte L, Fennell ML, Papandonatos G. The relationship of membership in research networks to compliance with treatment guidelines for early-stage breast cancer. Med Care 2005;43:471–9.*2005Breast cancerUSOB+P
 Rhyne R, Sussman AL, Fernald D, Weller N, Daniels E, Williams RL, et al. Reports of persistent change in the clinical encounter following research participation: a report from the Primary Care Multiethnic Network (PRIME Net). J Am Board Fam Med 2011;24:496–502. NigricansUSCS+P
 Siegel RM, Bien J, Lichtenstein P, Davis J, Khoury JC, Knight JE, et al. A safety-net antibiotic prescription for otitis media: the effects of a PBRN study on patients and practitioners. Clin Pediatr 2006;45:518–24. mediaUSCS+P
 Warnecke R, Johnson T, Kaluzny A, Ford L. The community clinical oncology program: its effect on clinical practice. J Qual Improv 1995;21:336–9.1995Breast cancerUSCS+P
Intervention papers
 Chaney EF, Rubenstein LV, Liu C-F, Yano EM, Bolkan C, Lee M, et al. Implementing collaborative care for depression treatment in primary care: a cluster randomized evaluation of a quality improvement practice redesign. Implement Sci 2011;6:121.
 Goldberg HI, Neighbor WE, Hirsch IB, Cheadle AD, Ramsey SD, Gore E. Evidence-based management: using serial firm trials to improve diabetes care quality. Joint Commission J Qual Improvement 2002;28:155–662002DiabetesUSOSM -P
 Hall C, Sigford B, Sayer N. Practice changes associated with the Department of Veterans Affairs’ Family Care Collaborative. J Gen Int Med 2010;25(Suppl. 1):18–26. for war veteransUSOS+P
 Puoane T, Sanders D, Ashworth A, Chopra M, Strasser S, McCoy D. Improving the hospital management of malnourished children by participatory research. Int J Qual Health Care 2004;16:31–40. in childrenS AfricaOSM+HO
  • *Paper that made an important contribution to the review (in terms of relevance, quality and size).

  • −, negative; +, positive; B, broader; C, clinicians; HO, health outcomes; M, mixed; O, organisations; P, processes of care; S, specific.

  • Adapted from Hanney, Boaz, Jones, Soper (2013)23.