Diagnostic accuracy of FENO in different patient collectives
| Pneumologists practice (n=393) p(asthma)=39.2% | General practice (n=160) p(asthma)=46.9% | |||
|---|---|---|---|---|
| NO [ppb] | Sensitivity | Specificity | Sensitivity | Specificity |
| ≥4 | 100 (97.6 to 100) | 0 (0 to 1.6) | 100 (95.1 to 100) | 0 (0 to 4.3) |
| ≥6 | 99.4 (96.5 to 99.9) | 2.1 (0.9 to 4.8) | 96.0 (88.9 to 98.6) | 7.1 (3.3 to 14.6) |
| ≥9 | 97.4 (93.5 to 99.0) | 7.5 (4.8 to 11.6) | 92.0 (83.6 to 96.3) | 15.3 (9.2 to 24.4) |
| ≥10 | 95.5 (91.0 to 97.8) | 13.0 (9.3 to 17.9) | 89.3 (80.3 to 94.5) | 16.5 (10.1 to 25.8) |
| ≥11 | 90.9 (85.3 to 94.5) | 18.8 (14.4 to 24.2) | 88.0 (78.7 to 93.6) | 20.0 (12.9 to 29.7) |
| ≥12 | 85.1 (78.6 to 89.9) | 28.5 (23.2 to 34.5) | 85.3 (75.6 to 91.6) | 23.5 (15.8 to 33.5) |
| ≥15 | 69.3 (76.6 to 82.6) | 36.4 (30.6 to 42.7) | 76.0 (65.2 to 84.3) | 37.6 (28.1 to 48.2) |
| ≥17 | 69.5 (61.8 to 76.2) | 47.3 (41.1 to 53.6) | 69.3 (58.1 to 78.6) | 52.9 (42.4 to 63.2) |
| ≥19 | 65.6 (57.8 to 72.6) | 55.2 (48.9 to 61.4) | 64.0 (52.7 to 73.9) | 57.6 (47.0 to 67.6) |
| ≥21 | 59.7 (51.8 to 67.1) | 63.2 (56.9 to 69.1) | 60.0 (48.7 to 70.3) | 61.2 (50.6 to 70.9) |
| ≥26 | 48.7 (40.9 to 56.5) | 75.3 (69.5 to 80.3) | 49.3 (38.3 to 60.4) | 72.9 (62.6 to 81.2) |
| ≥31 | 38.3 (31.0 to 46.2) | 83.3 (78.1 to 87.5) | 37.3 (27.2 to 48.6) | 76.5 (66.5 to 84.3) |
| ≥36 | 32.5 (25.6 to 40.2) | 87.9 (83.2 to 91.4) | 32.0 (22.5 to 43.2) | 83.5 (74.2 to 89.9) |
| ≥41 | 28.6 (22.1 to 36.2) | 90.8 (86.5 to 93.8) | 32.0 (22.5 to 43.2) | 88.2 (79.6 to 93.5) |
| ≥48 | 23.4 (17.4 to 30.7) | 92.5 (88.4 to 95.2) | 30.7 (21.4 to 41.9) | 92.9 (85.4 to 96.7) |
| ≥51 | 22.7 (16.8 to 29.9) | 93.7 (89.9 to 96.1) | 28.0 (19.1 to 39.0) | 92.9 (85.4 to 96.7) |
| ≥57 | 20.8 (15.1 to 27.9) | 95.4 (92.0 to 97.4) | 25.3 (16.8 to 36.2) | 94.1 (86.9 to 97.5) |
| ≥65 | 18.8 (13.4 to 25.7) | 95.8 (92.5 to 97.7) | 20.0 (12.5 to 30.4) | 98.8 (93.6 to 99.8) |
| ≥72 | 17.5 (12.3 to 24.3) | 97.1 (94.1 to 98.6) | 14.7 (8.4 to 24.4) | 98.8 (93.6 to 99.8) |
| ≥99 | 12.3 (8.0 to 18.4) | 99.2 (97.1 to 99.8) | 10.7 (5.5 to 19.7) | 100 (95.7 to 100) |
FENO, fractional exhaled nitric oxide; ppb, parts per billion.