Table 3

Allele association of five tagged SNPs in the normal group and hyperuricaemia group in the replication cohort

SNP amino acid change (rs number)GenotypeNormal uric acid groupHigh uric acid groupAllele frequencyAllele OR (95% CI)p Value
ControlCase
Discovery stageUA <4.5 mg/dL (<0.076 µmol/L)UA >8.5 mg/dL (>0.14 µmol/L)
 IVS7-103A/G (rs7929627)AA1770.320.532.37 (1.18 to 4.76) (R: A)0.015
AG1416
GG59
 IVS3+11A/G (rs75786299)GG362700.081.09 (1.01 to 1.17) (R: G)0.016
GA05
 N82N (rs3825017)CC27130.130.313.13 (1.30 to 7.52) (R: C)0.009
CT917
TT02
 -788A/T (rs11602903)AA15210.340.190.452 (0.204 to 1.003) (R: A)0.048
AT1810
TT31
 W258X (rs121907892)GG30320.0900.915 (0.853 to 0.983) (R: G)0.017
GA60
AA00
Replication stageUA < 4.1 mg/dL (<0.076 µmol/L)UA >8.7 mg/dL (<0.076 µmol/L)
 IVS7-103A/G (rs7929627)AA2361190.270.482.56 (2.10 to 3.12) (R: A)3.84×10−14
AG188228
GG26103
 IVS3+11A/G (rs75786299)GG449419<0.010.0332.07 (4.37 to 235.44) (R: G)1.20×10−8
GA131
 N82N (rs3825017)CC3452540.130.252.29 (1.78 to 2.93) (R: C)3.44×10−11
CT96168
TT928
 -788A/T (rs11602903)AA1362920.420.200.350 (0.284 to 0.432) (R: A)3.60×10−14
AT253136
TT6122
 W258X (rs121907892)GG2824500.1900.447 (0.424 to 0.472) (R: G)1.10×10−14
GA1640
AA40
  • p Value is determined by Pearson's χ2 test in the allele analysis.

  • R, reference allele.