Allele association of five tagged SNPs in the normal group and hyperuricaemia group in the replication cohort
SNP amino acid change (rs number) | Genotype | Normal uric acid group | High uric acid group | Allele frequency | Allele OR (95% CI) | p Value | |
---|---|---|---|---|---|---|---|
Control | Case | ||||||
Discovery stage | UA <4.5 mg/dL (<0.076 µmol/L) | UA >8.5 mg/dL (>0.14 µmol/L) | |||||
IVS7-103A/G (rs7929627) | AA | 17 | 7 | 0.32 | 0.53 | 2.37 (1.18 to 4.76) (R: A) | 0.015 |
AG | 14 | 16 | |||||
GG | 5 | 9 | |||||
IVS3+11A/G (rs75786299) | GG | 36 | 27 | 0 | 0.08 | 1.09 (1.01 to 1.17) (R: G) | 0.016 |
GA | 0 | 5 | |||||
N82N (rs3825017) | CC | 27 | 13 | 0.13 | 0.31 | 3.13 (1.30 to 7.52) (R: C) | 0.009 |
CT | 9 | 17 | |||||
TT | 0 | 2 | |||||
-788A/T (rs11602903) | AA | 15 | 21 | 0.34 | 0.19 | 0.452 (0.204 to 1.003) (R: A) | 0.048 |
AT | 18 | 10 | |||||
TT | 3 | 1 | |||||
W258X (rs121907892) | GG | 30 | 32 | 0.09 | 0 | 0.915 (0.853 to 0.983) (R: G) | 0.017 |
GA | 6 | 0 | |||||
AA | 0 | 0 | |||||
Replication stage | UA < 4.1 mg/dL (<0.076 µmol/L) | UA >8.7 mg/dL (<0.076 µmol/L) | |||||
IVS7-103A/G (rs7929627) | AA | 236 | 119 | 0.27 | 0.48 | 2.56 (2.10 to 3.12) (R: A) | 3.84×10−14 |
AG | 188 | 228 | |||||
GG | 26 | 103 | |||||
IVS3+11A/G (rs75786299) | GG | 449 | 419 | <0.01 | 0.03 | 32.07 (4.37 to 235.44) (R: G) | 1.20×10−8 |
GA | 1 | 31 | |||||
N82N (rs3825017) | CC | 345 | 254 | 0.13 | 0.25 | 2.29 (1.78 to 2.93) (R: C) | 3.44×10−11 |
CT | 96 | 168 | |||||
TT | 9 | 28 | |||||
-788A/T (rs11602903) | AA | 136 | 292 | 0.42 | 0.20 | 0.350 (0.284 to 0.432) (R: A) | 3.60×10−14 |
AT | 253 | 136 | |||||
TT | 61 | 22 | |||||
W258X (rs121907892) | GG | 282 | 450 | 0.19 | 0 | 0.447 (0.424 to 0.472) (R: G) | 1.10×10−14 |
GA | 164 | 0 | |||||
AA | 4 | 0 |
p Value is determined by Pearson's χ2 test in the allele analysis.
R, reference allele.