Table 1

Brief methodological details of all included studies

StudyNSettingParticipants (gender, age)ComorbiditiesAdjunct therapyIntervention (n-3PUFAs, dose)Comparison*DurationDepressive symptomology measure used in analysesAdverse events included in analyses
Bot et al, 20105125Clinical, The Netherlands52% female, mean age=54 yearsEPA—1 g/dayRapeseed oil+medium chain triglycerides12 weeksMADRS
Carney et al, 200952122Clinical, USA34% female, mean age=58 yearsEPA/DHA—0.93/0.75 g/dayCorn oil10 weeksHDRS (17 item)
Coryell unpublished (1.14 g/day)4611 (across both studies)Clinical/community, USA82% female, mean age=29 yearsPossibleEPA/DHA—0.74/0.4 g/dayOil6 weeksMADRS
Coryell unpublished (2.28 g/day)4611 (across both studies)Clinical/community, USA82% female, mean age=29 yearsPossibleEPA/DHA—1.48/0.8 g/dayOil6 weeksMADRS
da Silva et al, 2005 (AD)4731 (across both studies)Community, Brazil58% female, mean age=64 yearsEPA/DHA—0.72/0.48 g/dayMineral oil12 weeksMADRS
da Silva et al, 2005 (nAD)4731 (across both studies)Community, Brazil58% female, mean age=64 yearsXEPA/DHA—0.72/0.48 g/dayMineral oil12 weeksMADRS
Gertsik et al, 20125342Clinical/community, USAunknown gender distribution, mean age=41 yearsPossibleEPA/DHA/other n-3PUFAs—1.8/0.4/0.2 g/dayOlive oil8 weeksHDRS (21 item)
Gharekhani et al, 20145454Clinical, IranCompleters—44% female, mean age=57 yearsXEPA/DHA—1.08/0.72 g/dayParrafin oil16 weeksBDI
Gonzalez et al, 20115520Setting not reported, VenezuelaCompleters—80% female, mean age=39 yearsPossibleEPA—3 g/dayNot reported8 weeksHDRS (17 item)X
Grenyer et al, 20072383Clinical, Australia61% female, mean age=45 yearsPossiblePossibleEPA/DHA—0.56/2.2 g/dayOlive oil16 weeksHDRS (17 item)
Jazayeri et al 2008, (placebo)4860 (across both studies)Clincal, IranCompeters—69% female, mean age=35 yearsPossibleEPA—1 g/dayRapeseed oil8 weeksHDRS (24 item)X
Jazayeri et al, 2008, (AD)4860 (across both studies)Clincal, IranCompeters—69% female, mean age=35 yearsPossibleXEPA—1 g/day20 mg fluoxetine8 weeksHDRS (24 item)X
Lesperance et al, 201156432Clinical/community, Canada69% female, mean age=46 yearsPossiblePossibleEPA/DHA—1.05/0.15 g/daySunflower oil plus 2% fish oil8 weeksMADRS
Lucas et al, 20094529Community, Canada100% female, mean age=50 yearsPossibleXEPA/DHA—1.05/0.15 g/daySunflower oil plus 2% fish oil8 weeksHDRS (21 item)
Marangell et al, 20035736Setting not reportedCompleters—80% female, mean age=47 yearsXXDHA—2 g/dayNot reported6 weeksHDRS (28 item)X
Mischoulon et al, 20095841Clinical, USACompleted one postbaseline visit—63% female, mean age=43 yearsXPossibleEPA—1 g/dayParrafin oil8 weeksHDRS (17 item)
Mischoulon et al, 2015 (DHA)49196 (across both studies)Clinical, USACompleted one postbaseline visit—59% female, mean age=46 yearsPossibleXEPA/DHA/other n-3PUFAs—0.18/0.9/0.144 g/daySoybean oil8 weeksHDRS (17 item)
Mischoulon et al, 2015 (EPA)49196 (across both studies)Clinical, USACompleted one postbaseline visit—59% female, mean age=46 yearsPossibleXEPA/DHA/other n-3PUFAs—1.06/0.274/0.102 g/daySoybean oil8 weeksHDRS (17 item)
Nemets et al, 20021320Setting not reported85% female, mean age=53 yearsPossiblePossibleEPA—2 g/dayNot reported4 weeksHDRS (24 item)
Park et al, 20155935Clinical, Korea77% female, mean age=39 yearsPossibleEPA/DHA—3.42/1.8 g/daySafflower oil plus oleic acid12 weeksHDRS (17 item)
Peet and Horrobin, 2002 (1 g/day)5070 (across three studies)Clinical/community, UKGender distribution unknown, mean age=45 yearsPossibleEPA—1 g/dayParrafin oil12 weeksHDRS (17 item)
Peet and Horrobin, 2002 (2 g/day)5070 (across three studies)Clinical/community, UKGender distribution unknown, mean age=45 yearsPossibleEPA—2 g/dayParrafin oil12 weeksHDRS (17 item)
Peet and Horrobin, 2002 (4 g/day)5070 (across three studies)Clinical/community, UKGender distribution unknown, mean age=45 yearsPossibleEPA—4 g/dayParrafin oil12 weeksHDRS (17 item)
Rondanelli et al, 20106046Nursing home, Italy100% female, mean age=84 yearsPossiblePossibleEPA/DHA/other n-3PUFAs—1.67/0.83/0.63 g/dayParrafin oil8 weeksGDS
Silvers et al, 20052477Clinical/community, New Zealand53% female, mean age=39 yearsPossiblePossibleEPA/DHA—0.6/2.4 g/dayOlive oil12 weeksHDRS-SF (12 item)
Su et al, 20031428Clinical, TaiwanCompleters—82% female, mean age=38 yearsXPossibleEPA/DHA—4.4/2.2 g/dayOlive oil8 weeksHDRS (21 item)
  • *Comparison provided in a similar dose to that provided for the intervention.

  • BDI, Beck Depression Inventory;63 DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; GDS, Geriatric Depression Scale;64 HDRS, Hamilton Depression Rating Scale;62 MADRS, Montgomery Asberg Depression Rating Scale; n-3PUFA, n-3 polyunsaturated fatty acid.61