Characteristics of included randomised controlled trials
| Source | Number of patients (EGDT/control) | Design | Clinical setting | Study population | Goals in EGDT group | Goals in control group | Timing of EGDT | Mortality end point |
|---|---|---|---|---|---|---|---|---|
| Rivers et al 2001 | 263 (130/133) | P-R-NB-SC | ED | Adult patients with severe sepsis, septic shock or sepsis syndrome | SvO2 ≥70% CVP:8–12 mm Hg MAP:65–90 mm Hg UO ≥0.5 mL/kg/h | Standard therapy: CVP:8–12 mm Hg MAP:65–90 mm Hg UO ≥0.5 mL/kg/h | Within the first 6 h | Hospital 28-day 60-day |
| Yan et al 2010 | 303 (157/146) | P-R-NB-MC | ICU | Adult patients with severe sepsis or septic shock | ScvO2 ≥70% CVP:8–12 mm Hg SBP >90 mm Hg MAP ≥65 mm Hg UO ≥0.5 mL/kg/h | Standard therapy: CVP:8–12 mm Hg SBP >90 mm Hg MAP ≥65 mm Hg UO ≥0.5 mL/kg/h | Within the first 6 h | ICU 28-day |
| ProCESS 2014 | 895 (439/456) 885 (439/446) | P-R-NB-MC | ED/ICU | Adult patients with septic shock | ScvO2 ≥70% CVP:8–12 mm Hg MAP:65–90 mm Hg UO ≥0.5 mL/kg/h | Usual care Standard therapy: SBP ≥100 mm Hg | Within the first 6 h | 30-day 60-day 90-day |
| ARISE 2014 | 1591 (793/798) | P-R-NB-MC | ED/ICU | Adult patients with septic shock | ScvO2 ≥70% CVP:8–12 mm Hg MAP:65–90 mm Hg UO ≥0.5 mL/kg/h | Usual care | Within the first 6 h | ICU Hospital 28-day 60-day 90-day |
| ProMISe 2015 | 1251 (625/626) | P-R-MB-MC | ED/ICU | Adult patients with septic shock | ScvO2 ≥70% CVP ≥8 mm Hg MAP >60 mm Hg SBP >90 mm Hg | Usual care | Within the first 6 h | Hospital discharge 28-day 60-day 90-day |
CVP, central venous pressure; ED, emergency department; EGDT, early goal-directed therapy; ICU, intensive care unit; MAP, mean arterial pressure; MC, multicentre; NB, non-blinded; P, prospective; R, randomised; SBP, systolic blood pressure; SC, single centre; ScvO2, central venous oxygen saturation; SvO2, mixed venous oxygen saturation; UO, urine output.