Patient baseline characteristics for trials included in the NMA (N=41)
| First author | Year | Age Mean±SD | Male (%) | Diabetes duration (years) Mean±SD | HbA1c (%), Mean±SD | Body weight (kg) Mean±SD | |
|---|---|---|---|---|---|---|---|
| Gla-100 vs Gla-300 | Bolli8 | 2015 | 57.7±10.1 | 57.8 | 9.8±6.4 | 8.5±1.1 | 95.4±23.0 |
| Riddle6 | 2014 | 60.0±8.6 | 52.9 | 15.9±7.5 | 8.1±0.8 | 106.3±20.8 | |
| Yki-Järvinen7 | 2014 | 58.2±9.2 | 45.9 | 12.6±7.1 | 8.3±0.8 | 98.4±21.6 | |
| Gla-100 vs premixed | Aschner10 | 2013 | NA | NA | NA | 8.7±0 | NA |
| Buse11 | 2009 | 57.0±10 | 52.80 | 9.5±6.1 | 9.1±1.3 | 88.50±21.0 | |
| Fritsche12 | 2010 | 60.6±7.7 | 50.91 | 12.7±6.3 | 8.6±0.9 | 85.61±15.1 | |
| Jain13 | 2010 | 59.4±9.2 | 48.78 | 11.7±6.5 | 9.4±1.2 | 78.5±15.3 | |
| Kann14 | 2006 | 61.3±9.1 | 51.4 | 10.25±7.1 | 9.1±1.4 | 85.4±15.5 | |
| Kazda15 | 2006 | 59.4±9.5 | 54.7 | 5.6±2.9 | 8.1±1.2 | NA | |
| Ligthelm16 | 2011 | 52.7±10.4 | 56.66 | 11.15±6.4 | 9.0±1.1 | 97.9±20.5 | |
| Raskin17 | 2005 | 52.5±10.2 | 54.5 | 9.2±5.3 | 9.8±1.5 | 90.2±18.9 | |
| Riddle18 | 2011 | NA | NA | NA | NA | NA | |
| Robbins19 | 2007 | 57.8±9.1 | 49.9 | 11.9±6.3 | 7.8±1.0 | 88.6±19.7 | |
| Rosenstock20 | 2008 | 54.7±9.5 | 52.5 | 11.1±6.3 | 8.9±1.1 | 99.5±20.6 | |
| Strojek21 | 2009 | 56.0±9.9 | 43.96 | 9.3±6.0 | 8.5±1.1 | NA | |
| Tinahones22 | 2013 | NA | NA | NA | 8.6±0.8 | NA | |
| Vora23 | 2013 | NA | NA | NA | NA | NA | |
| Gla-100 vs NPH | Fritsche24 | 2003 | 61.0±9.0 | 53.7 | NA | 9.1±1.0 | 81.3±14.8 |
| MassiBenedetti25 | 2003 | 59.5±9.2 | 53.7 | 10.35±6.1 | 9.0±1.2 | NA | |
| Riddle26 | 2003 | 55.5±9.2 | 55.5 | 8.71±5.56 | 8.6±0.9 | NA | |
| Rosenstock27 | 2001 | 59.4±9.8 | 60.1 | 13.75±8.65 | 8.6±1.2 | 90.2±17.6 | |
| Rosenstock28 | 2009 | 55.1±8.7 | 53.9 | 10.75±6.8 | 8.4±1.4 | 99.5±22.5 | |
| Yki-Järvinen29 | 2006 | 56.5±1 | 63.3 | 9±1 | 9.5±0.1 | 93.1±2.5 | |
| Degludec vs Gla-100 | Garber30 | 2012 | 58.9±9.3 | 54.0 | 13.6±7.3 | 8.3±0.8 | 92.5±17.7 |
| Gough31 | 2013 | 57.6±9.2 | 53.2 | 8.2±6.2 | 8.3±1.0 | 92.5±18.5 | |
| Meneghini32 | 2013 | 56.5±9.6 | 53.7 | 10.6±6.7 | 8.4±0.9 | 81.7±16.7 | |
| Zinman33 | 2012 | 59.2±9.8 | 61.9 | 9.2±6.2 | 8.2±0.8 | 90.0±17.3 | |
| Zinman (PM)34 | 2013 | 57.4±10.2 | 57.2 | 8.8±3.4 | 8.3±0.8 | 91.9±18.5 | |
| Zinman (AM)34 | 2013 | 58.2±9.8 | 56.9 | 8.9±6.1 | 8.3±0.9 | 93.3±18.8 | |
| Detemir vs Gla-100 | Hollander35 | 2008 | 58.7±11 | 58.0 | 13.5±8.0 | 8.7±1.0 | 92.7±17.6 |
| Meneghini36 | 2013 | 57.3±10.3 | 56.5 | 8.2±6.1 | 7.91±0.6 | 82.3±16.7 | |
| Raskin37 | 2009 | 55.8±10.3 | 54.6 | 12.3±7.0 | 8.4±1 | 95.6±18.2 | |
| Rosenstock38 | 2008 | 58.9±9.9 | 57.9 | 9.1±6.3 | 8.6±0.8 | 87.4±17.0 | |
| Swinnen39 | 2010 | 58.4±8.3 | 54.7 | 9.9±5.8 | 8.7±0.9 | 83.9±17.1 | |
| Detemir vs premixed | Holman40 | 2007 | 61.7±9.8 | 64.1 | NA | 8.5±0.8 | 85.8±15.9 |
| Liebl41 | 2009 | 60.7±9.2 | 58.5 | 9.3±6.4 | 8.5±1.1 | NA | |
| Detemir vs NPH | Haak42 | 2005 | 60.4±8.6 | 51.1 | 13.2±7.6 | 7.9±1.3 | 86.9±15.8 |
| Hermansen43 | 2006 | 60.9±9.2 | 53.1 | 9.7±6.4 | 8.6±0.8 | 82.6±13.8 | |
| Montañana44 | 2008 | 61.9±8.8 | 40.6 | 16.3±8.0 | 8.85±1.0 | 81.0±12.1 | |
| Philis-Tsimakas45 | 2006 | 58.5±10.5 | 56.8 | 10.3±7.2 | 9.0±1.0 | NA | |
| Raslová46 | 2004 | 58.3±9.3 | 42.1 | 14.1±7.8 | 8.1±1.3 | 80.8±12.7 |
HbA1c, glycated haemoglobin; NA, not applicable; NMA, network meta-analysis; NPH, neutral protamine Hagedorn.