Table 1

Characteristics of the 22 studies included in the meta-analysis

StudyYearCountry and centresBlindingSample sizePopulationIntervention drugNesiritide bolus, µg/kgNesiritide infusion, µg/kg/minNesiritide duration, hControl drugFollow-up, monthsLost to follow-up, daysJadad score
Abraham et al192005MulticentresDouble blind489Acutely decompensated congestive heart failureNesiritide20.0124Nitroglycerin and placeboHosp05
Burger et al202001MulticentresOpen261Acutely decompensated congestive heart failureNesiritide0.30.015 and 0.03UNKDobutamine21 days03
Burger et al122002MulticentresOpen255Decompensated congestive heart failureNesiritide00.015 and 0.0324Dobutamine14 days03
O’Connor et al162011MulticentresDouble blind7141Acute heart failureNesiritide20.0124Placebo30 days05
Arora et al212007USA, single centreUNK206Acute decompensated heart failureNesiritide20.0124PlaceboHosp03
Silver et al222002MulticentresDouble blind261Decompensated heart failureNesiritide0.3 and 0.60.015 and 0.0324Dobutamine624
Witteles et al232007MulticentresDouble blind75Acute decompensated heart failureNesiritide20.0148Placebo30 days05
Aronson and Burger242002MulticentresUNK82Decompensated congestive heart failureNesiritideUNK0.015 and 0.0324DobutamineHosp04
The VMAC study112002MulticentresDouble blind489Decompensated congestive heart failureNesiritide10.0124Nitroglycerin and placebo605
Colucci et al82000MulticentresOpen432Symptomatic congestive heart failureNesiritide0.3 and 0.60.015 and 0.033Placebo21 days04
Chen et al252013MulticentresDouble blind360Acute heart failure and renal dysfunctionNesiritide00.00524Dobutamine and placebo180 days45
Chow et al262011USA, single centreOpen89Acutely decompensated heart failureNesiritide20.0124NitroglycerinHospUNK3
Peacock et al272005MulticentresDouble blind237Acutely decompensated heart failureNesiritide20.0112PlaceboHospUNK4
Peacock et al282004MulticentresDouble blind61Patients with dyspnoea at rest
resulting from heart failure
Nesiritide20.0124Nitroglycerin605
Peacock et al292005MulticentresDouble blind250Acutely decompensated heart failureNesiritide20.0112Placebo30 days15
Styron et al302009MulticentresUNK595Heart failureNesiritideUNKNAUNKPlacebo180days03
Carroll et al312007MulticentersOpen25 330Congestive heart failureNesiritideUNKNAUNKPlaceboHosp03
Yancy and Singh322006MulticentresOpen138Advanced heart failure and renal insufficiencyNesiritide1 and 20.005 and 0.0114 daysPlacebo343
Chow et al332011USA, single centreUNK89Cardiorenal syndrome with acute decompensated heart failureNesiritide20.0148Nitroglycerin603
Yancy et al342004MulticentresOpen210Decompensated heart failureNesiritide1 and 20.005 and 0.016Placebo303
Yancy et al352008MulticentresDouble blind911Acutely decompensated heart failureNesiritide20.016Placebo355
Mills et al361999MulticentresDouble blind103Decompensated heart failureNesiritide0.25, 0.5 and 1.00.015 and 0.0324PlaceboHospUNK5
  • Hosp, during hospitalisation; NA, not applicable; UNK, unknown.