Assumptions and calculations of target prices
| Medicine | Imatinib | Erlotinib | Sorafenib | Lapatinib |
|---|---|---|---|---|
| API per tablet | 400 mg | 150 mg | 200 mg | 250 mg |
| Tablets per month | 28 | 28 | 112 | 168 |
| API price per kilogram | $347–$746 | $2470 | $3000 | $4671 |
| API cost per tablet | $0.14–$0.30 | $0.37 | $0.60 | $1.17 |
| Add cost of excipients and formulation | $0.18–$0.34 | $0.38 | $0.62 | $1.18 |
| Add cost of tableting | $0.22–$0.38 | $0.42 | $0.66 | $1.22 |
| Cost per month | $6.22–$10.68 | $11.90 | $73.83 | $205.26 |
| Add cost of bottle, packaging, shipping, duties | $6.57–$11.03 | $12.25 | $74.18 | $205.61 |
| Add 50% mark-up | $9.85–$16.55 | $18.37 | $111.27 | $308.41 |
| Target price per year | $128–$216 | $240 | $1450 | $4020 |
The prices of excipients used for each TKI are given in text, but not shown in table.
API, active pharmaceutical ingredient; TKI, tyrosine kinase inhibitor.