PT  - JOURNAL ARTICLE
AU  - Jacquelyn D Marsh
AU  - Trevor B Birmingham
AU  - J Robert Giffin
AU  - Wanrudee Isaranuwatchai
AU  - Jeffrey S Hoch
AU  - Brian G Feagan
AU  - Robert Litchfield
AU  - Kevin Willits
AU  - Peter Fowler
TI  - Cost-effectiveness analysis of arthroscopic surgery compared with non-operative management for osteoarthritis of the knee
AID  - 10.1136/bmjopen-2015-009949
DP  - 2016 Jan 01
TA  - BMJ Open
PG  - e009949
VI  - 6
IP  - 1
4099  - http://bmjopen.bmj.com/content/6/1/e009949.short
4100  - http://bmjopen.bmj.com/content/6/1/e009949.full
SO  - BMJ Open2016 Jan 01; 6
AB  - Objective To determine the cost-effectiveness of arthroscopic surgery in addition to non-operative treatments compared with non-operative treatments alone in patients with knee osteoarthritis (OA).Design, setting and participants We conducted an economic evaluation alongside a single-centre, randomised trial among patients with symptomatic, radiographic knee OA (KL grade ≥2).Interventions Patients received arthroscopic debridement and partial resection of degenerative knee tissues in addition to optimised non-operative therapy, or optimised non-operative therapy only.Main outcome measures Direct and indirect costs were collected prospectively over the 2-year study period. The effectiveness outcomes were the Western Ontario McMaster Osteoarthritis Index (WOMAC) and quality-adjusted life years (QALYs). Cost-effectiveness was estimated using the net benefit regression framework considering a range of willingness-to-pay values from the Canadian public payer and societal perspectives. We calculated incremental cost-effectiveness ratios and conducted sensitivity analyses using the extremes of the 95% CIs surrounding mean differences in effect between groups.Results 168 patients were included. Patients allocated to arthroscopy received partial resection and debridement of degenerative meniscal tears (81%) and/or articular cartilage (97%). There were no significant differences between groups in use of non-operative treatments. The incremental net benefit was negative for all willingness-to-pay values. Uncertainty estimates suggest that even if willing to pay $400 000 to achieve a clinically important improvement in WOMAC score, or ≥$50 000 for an additional QALY, there is <20% probability that the addition of arthroscopy is cost-effective compared with non-operative therapies only. Our sensitivity analysis suggests that even when assuming the largest treatment effect, the addition of arthroscopic surgery is not economically attractive compared with non-operative treatments only.Conclusions Arthroscopic debridement of degenerative articular cartilage and resection of degenerative meniscal tears in addition to non-operative treatments for knee OA is not an economically attractive treatment option compared with non-operative treatment only, regardless of willingness-to-pay value.Trial registration number NCT00158431.