TY - JOUR T1 - Association of endothelial lipase gene−384A/C with coronary artery disease in Han Chinese people JF - BMJ Open JO - BMJ Open DO - 10.1136/bmjopen-2015-007621 VL - 5 IS - 6 SP - e007621 AU - Liang Xie AU - Yan Sun AU - Yu Tong AU - Ying Liu AU - Ying Deng Y1 - 2015/06/01 UR - http://bmjopen.bmj.com/content/5/6/e007621.abstract N2 - Objectives The endothelial lipase gene (LIPG) is one of the important genes in the metabolism of high-density lipoprotein cholesterol (HDL-C) and may be involved in the pathogenesis of coronary artery disease (CAD).Materials and methods To investigate the relationship between the common single nucleotide polymorphisms (SNPs) 584C/T (rs2000813) and −384A/C (rs3813082) in the LIPG gene and CAD, allele and genotype frequencies of the two SNPs were analysed in 287 Chinese patients with CAD and 367 controls by the high-resolution melting curve (HRM) method.Results For 584C/T, no significant difference in polymorphic distribution was observed between patients and controls. However, the frequencies of allele C (20.2% vs 15%, p=0.013, OR=1.437, 95% CI 1.078 to 1.915) at −384A/C were significantly increased in patients compared with controls. Haplotype analysis also showed that haplotype CT (12.37% vs 8.72%, p=0.035, OR=1.478, 95% CI 1.034 to 2.112) was significantly higher in patients compared with controls.Conclusions These results suggested that the SNP −384A/C in the LIPG gene may be associated with risk for CAD and the LIPG gene may play a role in CAD in the Han Chinese. ER -