RT Journal Article
SR Electronic
T1 The design of a multicentre Canadian surveillance study of sedation safety in the paediatric emergency department
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e008223
DO 10.1136/bmjopen-2015-008223
VO 5
IS 5
A1 Maala Bhatt
A1 Mark G Roback
A1 Gary Joubert
A1 Ken J Farion
A1 Samina Ali
A1 Suzanne Beno
A1 C Michelle McTimoney
A1 Andrew Dixon
A1 Alexander Sasha Dubrovsky
A1 Nick Barrowman
A1 David W Johnson
YR 2015
UL http://bmjopen.bmj.com/content/5/5/e008223.abstract
AB Introduction Procedural sedation and analgesia have become standard practice in paediatric emergency departments worldwide. Although generally regarded as safe, serious adverse events such as bradycardia, asystole, pulmonary aspiration, permanent neurological injury and death have been reported, but their incidence is unknown due to the infrequency of their occurrence and lack of surveillance of sedation safety. To improve our understanding of the safety, comparative effectiveness and variation in care in paediatric procedural sedation, we are establishing a multicentre patient registry with the goal of conducting regular and ongoing surveillance for adverse events in procedural sedation.Methods This multicentre, prospective cohort study is enrolling patients under 18 years of age from six paediatric emergency departments across Canada. Data collection is fully integrated into clinical care and is performed electronically in real time by the healthcare professionals caring for the patient. The primary outcome is the proportion of patients who experience a serious adverse event as a result of their sedation. Secondary outcomes include the proportion of patients who experience an adverse event that could lead to a serious adverse event, proportion of patients who receive a significant intervention in response to an adverse event, proportion of patients who experience a successful sedation, and proportion of patients who experience a paradoxical reaction to sedation. There is no predetermined end date for data collection.Ethics and dissemination Ethics approval has been obtained from participating sites. Results will be disseminated using a multifaceted knowledge translation strategy by presenting at international conferences, publication in peer-reviewed journals, and through established networks.