RT Journal Article
SR Electronic
T1 Pre-existing type 2 diabetes and risk of lung cancer: a report from two prospective cohort studies of 133 024 Chinese adults in urban Shanghai
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e004875
DO 10.1136/bmjopen-2014-004875
VO 4
IS 7
A1 Wan-Shui Yang
A1 Yang Yang
A1 Gong Yang
A1 Wong-Ho Chow
A1 Hong-Lan Li
A1 Yu-Tang Gao
A1 Bu-Tian Ji
A1 Nat Rothman
A1 Wei Zheng
A1 Xiao-Ou Shu
A1 Yong-Bing Xiang
YR 2014
UL http://bmjopen.bmj.com/content/4/7/e004875.abstract
AB Objectives Observational studies of type 2 diabetes (T2D) and lung cancer risk are limited and controversial. We thus examined the association between T2D and risk of incident lung cancer using a cohort design. Setting Data from two ongoing population-based cohorts (the Shanghai Men's Health Study, SMHS, 2002–2006 and the Shanghai Women's Health Study, SWHS, 1996–2000) were used. Cox proportional-hazards regression models with T2D as a time-varying exposure were modelled to estimate HRs and 95% CIs. Participants The study population included 61 491 male participants aged 40–74 years from SMHS and 74 941 female participants aged 40–70 years from SWHS. Outcome measure Lung cancer cases were identified through annual record linkage to the Shanghai Cancer Registry and Shanghai Municipal Registry of Vital Statistics, and were further verified through home visits and a review of medical charts by clinical and/or pathological experts. Outcome data until 31 December 2010 for men and women were used for the present analysis. Results After a median follow-up of 6.3 years for SMHS and 12.2 years for SWHS, incident lung cancer cases were detected in 492 men and 525 women. A null association between T2D and lung cancer risk was observed in men (HR=0.87, 95% CI 0.62 to 1.21) and women (HR=0.92, 95% CI 0.69 to 1.24) after adjustments for potential confounders. Similar results were observed among never smokers. Conclusions There is little evidence that pre-existing T2D may influence the incidence of lung cancer.