%0 Journal Article %A Shinichiro Hibi %A Yasuhiro Yamaguchi %A Yumi Umeda-Kameyama %A Katsuya Iijima %A Miwako Takahashi %A Toshimitsu Momose %A Masahiro Akishita %A Yasuyoshi Ouchi %T Respiratory dysrhythmia in dementia with Lewy bodies: a cross-sectional study %D 2013 %R 10.1136/bmjopen-2013-002870 %J BMJ Open %P e002870 %V 3 %N 9 %X Objectives Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). DLB is characterised by intracytoplasmic inclusions called Lewy bodies that are often seen in the brainstem. Because modulation of the respiratory rhythm is one of the most important functions of the brainstem, patients with DLB may exhibit dysrhythmic breathing. This hypothesis has not yet been systematically studied. Therefore, we evaluated the association between DLB and dysrhythmic breathing. Design In this cross-sectional study consecutive inpatients who were admitted for the evaluation of progressive cognitive impairment were enrolled. We assessed breathing irregularity using polysomnographic recordings on bed rest with closed eyes, without reference to the clinical differentiation among DLB, AD and having no dementia. Setting Single centre in Japan. Participants 14 patients with DLB , 21 with AD and 12 without dementia were enrolled in this study. Primary outcome measures The coefficient of variation (CV) of the breath-to-breath time was calculated. We also examined the amplitude spectrum A(f) obtained using the fast Fourier transform and Shannon entropy S of A(f) in patients with DLB compared with patients with AD and patients without dementia. Results The values of CV and entropy S were significantly higher in patients with DLB than in patients with AD and patients without dementia. No significant differences were observed between patients with AD and patients without dementia. Conclusions Patients with DLB exhibit dysrhythmic breathing compared with patients with AD and patients without dementia. Dysrhythmic breathing is a new clinical feature of DLB and the spectral analysis of breathing patterns can be clinically useful for the diagnostic differentiation of DLB from AD. %U https://bmjopen.bmj.com/content/bmjopen/3/9/e002870.full.pdf