TY - JOUR T1 - National trends in hospital-acquired preventable adverse events after major cancer surgery in the USA JF - BMJ Open JO - BMJ Open DO - 10.1136/bmjopen-2013-002843 VL - 3 IS - 6 SP - e002843 AU - Shyam Sukumar AU - Florian Roghmann AU - Vincent Q Trinh AU - Jesse D Sammon AU - Mai-Kim Gervais AU - Hung-Jui Tan AU - Praful Ravi AU - Simon P Kim AU - Jim C Hu AU - Pierre I Karakiewicz AU - Joachim Noldus AU - Maxine Sun AU - Mani Menon AU - Quoc-Dien Trinh Y1 - 2013/06/01 UR - http://bmjopen.bmj.com/content/3/6/e002843.abstract N2 - Objectives While multiple studies have demonstrated variations in the quality of cancer care in the USA, payers are increasingly assessing structure-level and process-level measures to promote quality improvement. Hospital-acquired adverse events are one such measure and we examine their national trends after major cancer surgery. Design Retrospective, cross-sectional analysis of a weighted-national estimate from the Nationwide Inpatient Sample (NIS) undergoing major oncological procedures (colectomy, cystectomy, oesophagectomy, gastrectomy, hysterectomy, lung resection, pancreatectomy and prostatectomy). The Agency for Healthcare Research and Quality Patient Safety Indicators (PSIs) were utilised to identify trends in hospital-acquired adverse events. Setting Secondary and tertiary care, US hospitals in NIS Participants A weighted-national estimate of 2 508 917 patients (>18 years, 1999–2009) from NIS. Primary outcome measures Hospital-acquired adverse events. Results 324 852 patients experienced ≥1-PSI event (12.9%). Patients with ≥1-PSI experienced higher rates of in-hospital mortality (OR 19.38, 95% CI 18.44 to 20.37), prolonged length of stay (OR 4.43, 95% CI 4.31 to 4.54) and excessive hospital-charges (OR 5.21, 95% CI 5.10 to 5.32). Patients treated at lower volume hospitals experienced both higher PSI events and failure-to-rescue rates. While a steady increase in the frequency of PSI events after major cancer surgery has occurred over the last 10 years (estimated annual % change (EAPC): 3.5%, p<0.001), a concomitant decrease in failure-to-rescue rates (EAPC −3.01%) and overall mortality (EAPC −2.30%) was noted (all p<0.001). Conclusions Over the past decade, there has been a substantial increase in the national frequency of potentially avoidable adverse events after major cancer surgery, with a detrimental effect on numerous outcome-level measures. However, there was a concomitant reduction in failure-to-rescue rates and overall mortality rates. Policy changes to improve the increasing burden of specific adverse events, such as postoperative sepsis, pressure ulcers and respiratory failure, are required. ER -