RT Journal Article
SR Electronic
T1 A cohort study on the rate of progression of diabetic chronic kidney disease in different ethnic groups
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e001855
DO 10.1136/bmjopen-2012-001855
VO 3
IS 2
A1 Omer Ali
A1 Atif Mohiuddin
A1 Rohini Mathur
A1 Gavin Dreyer
A1 Sally Hull
A1 Muhammad M Yaqoob
YR 2013
UL http://bmjopen.bmj.com/content/3/2/e001855.abstract
AB Objective To compare the rate of progression of diabetic chronic kidney disease in different ethnic groups. Design Prospective longitudinal observational study. Participants All new patients attending a tertiary renal unit in east London with diabetic chronic kidney disease between 2000 and 2007 and followed up till 2009 were included. Patients presenting with acute end-stage kidney failure were excluded. Main outcome measures The primary outcome was annual decline in the estimated glomerular filtration rate (eGFR) in different ethnic groups. Secondary end points were the number of patients developing end-stage kidney failure and total mortality during the study period. Results 329 patients (age 60±11.9 years, 208 men) were studied comprising 149 south Asian, 105 White and 75 Black patients. Mean follow-up was 6.0±2.3, 5.0±2.7 and 5.6±2.4 years for White, Black and south Asian patients, respectively. South Asian patients were younger and had a higher baseline eGFR, but both systolic and diastolic blood pressures were higher in Black patients (p<0.05). Baseline proteinuria was highest for the south Asian group followed by the White and Black groups. Adjusted linear regression analysis showed that an annual decline in eGFR was not significantly different between the three groups. The numbers of patients developing end-stage kidney failure and total mortality were also not significantly different between the three groups. ACE or angiotensin receptor blockers use, and glycated haemoglobin were similar at baseline and throughout the study period. Conclusions We conclude that ethnicity is not an independent factor in the rate of progression renal failure in patients with diabetic chronic kidney disease.