PT  - JOURNAL ARTICLE
AU  - Stephen Bernard Lambert
AU  - Robert S Ware
AU  - Anne L Cook
AU  - Frances A Maguire
AU  - David M Whiley
AU  - Seweryn Bialasiewicz
AU  - Ian M Mackay
AU  - David Wang
AU  - Theo P Sloots
AU  - Michael D Nissen
AU  - Keith Grimwood
TI  - Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study
AID  - 10.1136/bmjopen-2012-002134
DP  - 2012 Jan 01
TA  - BMJ Open
PG  - e002134
VI  - 2
IP  - 6
4099  - http://bmjopen.bmj.com/content/2/6/e002134.short
4100  - http://bmjopen.bmj.com/content/2/6/e002134.full
SO  - BMJ Open2012 Jan 01; 2
AB  - Introduction Even in developed economies infectious diseases remain the most common cause of illness in early childhood. Our current understanding of the epidemiology of these infections is limited by reliance on data from decades ago performed using low-sensitivity laboratory methods, and recent studies reporting severe, hospital-managed disease. Methods and analysis The Observational Research in Childhood Infectious Diseases (ORChID) study is an ongoing study enrolling a dynamic birth cohort to document the community-based epidemiology of viral respiratory and gastrointestinal infections in early childhood. Women are recruited antenatally, and their healthy newborn is followed for the first 2 years of life. Parents keep a daily symptom diary for the study child, collect a weekly anterior nose swab and dirty nappy swab and complete a burden diary when a child meets pre-defined illness criteria. Specimens will be tested for a wide range of viruses by real-time PCR assays. Primary analyses involves calculating incidence rates for acute respiratory illness (ARI) and acute gastroenteritis (AGE) for the cohort by age and seasonality. Control material from children when they are without symptoms will allow us to determine what proportion of ARIs and AGE can be attributed to specific pathogens. Secondary analyses will assess the incidence and shedding duration of specific respiratory and gastrointestinal pathogens. Ethics and dissemination This study is approved by The Human Research Ethics Committees of the Children's Health Queensland Hospital and Health Service, the Royal Brisbane and Women's Hospital and The University of Queensland. Trial registration clinicaltrials.gov NCT01304914.