PT  - JOURNAL ARTICLE
AU  - Mota Neto, José
AU  - Mendes, Adriano Fernando
AU  - Martins, Anita Fernanda Magalhães
AU  - Landa, Aline Teixeira de
AU  - Fraga, Rafael de Oliveira
AU  - Souza, Viviane Angelina de
AU  - Raposo, Nádia Rezende Barbosa
TI  - Protocol of HOTFy: randomised clinical trial to hyperbaric oxygen therapy in fibromyalgia
AID  - 10.1136/bmjopen-2022-069153
DP  - 2023 Jan 01
TA  - BMJ Open
PG  - e069153
VI  - 13
IP  - 1
4099  - http://bmjopen.bmj.com/content/13/1/e069153.short
4100  - http://bmjopen.bmj.com/content/13/1/e069153.full
SO  - BMJ Open2023 Jan 01; 13
AB  - Introduction Fibromyalgia is a polysymptomatic syndrome with a prevalence between 0.2% and 13% of the population and causes work disabilities in approximately half of affected patients. Several treatments to fibromyalgia have been proposed with partial improvement. This study aims to evaluate the efficacy of hyperbaric oxygen therapy and when it should be introduced to fibromyalgia.Methods and analysis This is a protocol for an open-label, crossover, randomised clinical trial comparing treatment with hyperbaric oxygen therapy and standardised treatment to fibromyalgia. In the proposed study, 56 individuals with fibromyalgia will be randomised in a 1:1 ratio into a single, fixed, random block, in which one group will receive hyperbaric oxygen therapy and another will receive standard treatment. Subsequently, the groups will be crossed. Participants will be evaluated at baseline, eight and 16 weeks based on functional impairment assessed with the Fibromyalgia Impact Questionnaire—Brazilian Portuguese version, psychopathological symptoms questionnaire and short-form quality of life questionnaire. The improvement of symptoms concerning the moment of therapy used will be compared between groups. For sample size calculation, a moderate effect size, 80% power and 95% CI will be estimated, in a total of 46 patients. Considering a dropout of 20%, 56 patients should be recruited.Ethics and dissemination The study was approved by the Universidade Federal de Juiz de Fora Teaching Hospital ethics committee and assigned the number 53058421.9.0000.5133 (version 3). The results will be disseminated via publications in peer-reviewed journals and presentations in medical meetings.Trial registration number RBR-6prps8g)/UTN U1111-1278-3224.