PT  - JOURNAL ARTICLE
AU  - Laurie W Smith
AU  - C Sarai Racey
AU  - Lovedeep Gondara
AU  - Mel Krajden
AU  - Marette Lee
AU  - Ruth Elwood Martin
AU  - Gavin Stuart
AU  - Stuart Peacock
AU  - Andrew J Coldman
AU  - Eduardo L Franco
AU  - Dirk van Niekerk
AU  - Gina S Ogilvie
TI  - Women’s acceptability of and experience with primary human papillomavirus testing for cervix screening: HPV FOCAL trial cross-sectional online survey results
AID  - 10.1136/bmjopen-2021-052084
DP  - 2021 Oct 01
TA  - BMJ Open
PG  - e052084
VI  - 11
IP  - 10
4099  - http://bmjopen.bmj.com/content/11/10/e052084.short
4100  - http://bmjopen.bmj.com/content/11/10/e052084.full
SO  - BMJ Open2021 Oct 01; 11
AB  - Objective To study participant’s acceptability of and attitudes towards human papillomavirus (HPV) testing compared with cytology for cervical cancer screening and what impact having an HPV positive result may have in future acceptability of screening.Design Cross-sectional online survey of clinical trial participants.Setting Primary care, population-based Cervix Screening Program, British Columbia, Canada.Participants A total of 5532 participants from the HPV FOCAL trial, in which women received HPV and cytology testing at study exit, were included in the analysis. Median age was 54 years. The median time of survey completion was 3 years after trial exit.Outcome measures Acceptability of HPV testing for primary cervical cancer screening (primary); attitudes and patient perceptions towards HPV testing and receipt of HPV positive screen results (secondary).Results Most respondents (63%) were accepting of HPV testing, with the majority (69%) accepting screening to begin at age 30 years with HPV testing. Only half of participants (54%) were accepting of an extended screening interval of 4–5 years. In multivariable logistic regression, women who received an HPV positive screen test result during the trial (OR=1.41 95% CI 1.11 to 1.80) or were older (OR=1.01, 95% CI 1.00 to 1.02) were more likely to report HPV testing as acceptable.Conclusions In this evaluation of acceptability and attitudes regarding HPV testing for cervix screening, most are accepting of HPV testing for screening; however, findings indicate heterogeneity in concerns and experiences surrounding HPV testing and receipt of HPV positive results. These findings provide insights for the development of education, information and communication strategies during implementation of HPV-based cervical cancer screening.Trial registration numbers ISRCTN79347302 and NCT00461760.Data are available on reasonable request. Deidentified participant data is available upon consideration and reasonable request.