TY - JOUR T1 - Association between tissue oxygenation and myocardial injury in patients undergoing major spine surgery: a prospective cohort study JF - BMJ Open JO - BMJ Open DO - 10.1136/bmjopen-2020-044342 VL - 11 IS - 9 SP - e044342 AU - Katrine Feldballe Bernholm AU - Christian S. Meyhoff AU - Philip Bickler Y1 - 2021/09/01 UR - http://bmjopen.bmj.com/content/11/9/e044342.abstract N2 - Objective To describe the association between intraoperative tissue oxygenation and postoperative troponin elevation in patients undergoing major spine surgery. We hypothesised that a decrease in intraoperative skeletal muscle tissue oxygenation (SmO2) was associated with the peak postoperative cardiac troponin value.Design This is a prospective cohort study.Setting Single-centre, University of California San Francisco Medical Center.Participants Seventy adult patients undergoing major elective spine surgery.Primary and secondary outcome measures High-sensitivity troponin T (hsTnT) was measured in plasma preoperatively and on the first and second day after surgery to assess the primary outcome of peak postoperative hsTnT. Secondary outcomes included MINS and intensive care unit (ICU) admission within 30 days. Skeletal cerebral tissue oxygenation and SmO2 was measured continuously with near-infrared spectroscopy during surgery. The primary exposure variable was time-weighted area under the curve (TW AUC) for SmO2.Results Mean age was 65 (33–85) years and 59% were female. No significant association was found between TW AUC for SmO2 and peak hsTnT (Spearman’s correlation, rs=0.17, p=0.16). A total of 28 (40%) patients had MINS. ICU admission occurred in 14 (40%) in lower vs 25 (71%) in upper half of patients based on TW AUC for SmO2, p=0.008.Conclusions Decrease in SmO2 was not a statistically significant predictor for peak troponin value following major spine surgery but is a potential predictor for other postoperative complications.Trial registration number NCT03518372.Data are available on reasonable request. Anonymised data will be made available upon reasonable request. ER -