RT Journal Article
SR Electronic
T1 Association of cardiometabolic risk factors with hospitalisation or death due to COVID-19: population-based cohort study in Sweden (SCAPIS)
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e051359
DO 10.1136/bmjopen-2021-051359
VO 11
IS 9
A1 Tornhammar, Per
A1 Jernberg, Tomas
A1 Bergström, Göran
A1 Blomberg, Anders
A1 Engström, Gunnar
A1 Engvall, Jan
A1 Fall, Tove
A1 Gisslén, Magnus
A1 Janson, Christer
A1 Lind, Lars
A1 Sköld, C Magnus
A1 Sundström, Johan
A1 Söderberg, Stefan
A1 Zaigham, Suneela
A1 Östgren, Carl Johan
A1 Andersson, Daniel Peter
A1 Ueda, Peter
YR 2021
UL http://bmjopen.bmj.com/content/11/9/e051359.abstract
AB Objective To assess the association of cardiometabolic risk factors with hospitalisation or death due to COVID-19 in the general population.Design, setting and participants Swedish population-based cohort including 29 955 participants.Exposures Cardiometabolic risk factors assessed between 2014 and 2018.Main outcome measures Hospitalisation or death due to COVID-19, as registered in nationwide registers from 31 January 2020 through 12 September 2020. Associations of cardiometabolic risk factors with the outcome were assessed using logistic regression adjusted for age, sex, birthplace and education.Results Mean (SD) age was 61.2 (4.5) and 51.5% were women. 69 participants experienced hospitalisation or death due to COVID-19. Examples of statistically significant associations between baseline factors and subsequent hospitalisation or death due to COVID-19 included overweight (adjusted OR (aOR) vs normal weight 2.73 (95% CI 1.25 to 5.94)), obesity (aOR vs normal weight 4.09 (95% CI 1.82 to 9.18)), pre-diabetes (aOR vs normoglycaemia 2.56 (95% CI 1.44 to 4.55)), diabetes (aOR vs normoglycaemia 3.96 (95% CI 2.13 to 7.36)), sedentary time (aOR per hour/day increase 1.10 (95% CI 1.02 to 1.17)), grade 2 hypertension (aOR vs normotension 2.44 (95% CI 1.10 to 5.44)) and high density lipoprotein cholesterol (aOR per mmol/L increase 0.33 (95% CI 0.17 to 0.65)). Statistically significant associations were not observed for grade 1 hypertension (aOR vs normotension 1.03 (95% CI 0.55 to 1.96)), current smoking (aOR 0.56 (95% CI 0.24 to 1.30)), total cholesterol (aOR per mmol/L increase 0.90 (95% CI 0.71 to 1.13)), low density lipoprotein cholesterol (aOR per mmol/L increase 0.90 (95% CI 0.69 to 1.15)) and coronary artery calcium score (aOR per 10 units increase 1.00 (95% CI 0.99 to 1.01)).Conclusions In a large population-based sample from the general population, several cardiometabolic risk factors were associated with hospitalisation or death due to COVID-19.No data are available.