PT - JOURNAL ARTICLE AU - Lisette Mignot-Evers AU - Vivian Raaijmakers AU - Gerba Buunk AU - Steffie Brouns AU - Lorenzo Romano AU - Thijs van Herpt AU - Arvind Gharbharan AU - Jeanne Dieleman AU - Harm Haak TI - Comparison of SIRS criteria and qSOFA score for identifying culture-positive sepsis in the emergency department: a prospective cross-sectional multicentre study AID - 10.1136/bmjopen-2020-041024 DP - 2021 Jun 01 TA - BMJ Open PG - e041024 VI - 11 IP - 6 4099 - http://bmjopen.bmj.com/content/11/6/e041024.short 4100 - http://bmjopen.bmj.com/content/11/6/e041024.full SO - BMJ Open2021 Jun 01; 11 AB - Objective To compare the daily practice of two emergency departments (ED) in the Netherlands, where systemic inflammatory response syndrome (SIRS) criteria and quick Sequential Organ Failure Assessment (qSOFA) score are used differently as screening tools for culture-positive sepsis.Design A prospective cross-sectional multicentre study.Setting Two EDs at two European clinical teaching hospitals in the Netherlands.Participants 760 patients with suspected infection who met SIRS criteria or had a qualifying qSOFA score who were treated at two EDs in the Netherlands from 1 January to 1 March 2018 were included.Methods SIRS criteria and qSOFA score were calculated for each patient. The first hospital treated the patients who met SIRS criteria following the worldwide Surviving Sepsis Campaign protocol. At the second hospital, only patients who met the qualifying qSOFA score received this treatment. Therefore, patients could be divided into five groups: (1) SIRS+, qSOFA−, not treated according to protocol (reference group); (2) SIRS+, qSOFA−, treated according to protocol; (3) SIRS+, qSOFA+, treated according to protocol; (4) SIRS−, qSOFA+, not treated according to protocol; (5) SIRS−, qSOFA+, treated according to protocol.Primary and secondary outcome measures To prove culture-positive sepsis was present, cultures were used as the primary outcome. Secondary outcomes were in-hospital mortality and intensive care unit (ICU) admission.Results 98.9% met SIRS criteria and 11.7% met qSOFA score. Positive predictive values of SIRS criteria and qSOFA score were 41.2% (95% CI 37.4% to 45.2%) and 48.1% (95% CI 37.4% to 58.9%), respectively. HRs were 0.79 (95% CI 0.40 to 1.56, p=0.500), 3.42 (95% CI 1.82 to 6.44, p<0.001), 18.94 (95% CI 2.48 to 144.89, p=0.005) and 4.97 (95% CI 1.44 to 17.16, p=0.011) for groups 2–5, respectively.Conclusion qSOFA score performed as well as SIRS criteria for identifying culture-positive sepsis and performed significantly better for predicting in-hospital mortality and ICU admission. This study shows that SIRS criteria are no longer necessary and recommends qSOFA score as the standard for identifying culture-positive sepsis in the ED.Trial registration number NL8315.Data are available in a public, open-access repository. Extra data can be accessed via the Dryad data repository at http://datadryad.org/withthedoi.org/10.5061/dryad.d2547d82n.