PT  - JOURNAL ARTICLE
AU  - Susan Alcock
AU  - Divjeet Batoo
AU  - Sudharsana Rao Ande
AU  - Rob Grierson
AU  - Marco Essig
AU  - Douglas Martin
AU  - Anurag Trivedi
AU  - Namita Sinha
AU  - Murdoch Leeies
AU  - Frederick A Zeiler
AU  - Jai Jai Shiva Shankar
TI  - Early diagnosis of mortality using admission CT perfusion in severe traumatic brain injury patients (ACT-TBI): protocol for a prospective cohort study
AID  - 10.1136/bmjopen-2020-047305
DP  - 2021 Jun 01
TA  - BMJ Open
PG  - e047305
VI  - 11
IP  - 6
4099  - http://bmjopen.bmj.com/content/11/6/e047305.short
4100  - http://bmjopen.bmj.com/content/11/6/e047305.full
SO  - BMJ Open2021 Jun 01; 11
AB  - Introduction Severe traumatic brain injury (TBI) is a catastrophic neurological condition with significant economic burden. Early in-hospital mortality (<48 hours) with severe TBI is estimated at 50%. Several clinical examinations exist to determine brain death; however, most are difficult to elicit in the acute setting in patients with severe TBI. Having a definitive assessment tool would help predict early in-hospital mortality in this population. CT perfusion (CTP) has shown promise diagnosing early in-hospital mortality in patients with severe TBI and other populations. The purpose of this study is to validate admission CTP features of brain death relative to the clinical examination outcome for characterizing early in-hospital mortality in patients with severe TBI.Methods and analysis The Early Diagnosis of Mortality using Admission CT Perfusion in Severe Traumatic Brain Injury Patients study, is a prospective cohort study in patients with severe TBI funded by a grant from the Canadian Institute of Health Research. Adults aged 18 or older, with evidence of a severe TBI (Glasgow Coma Scale score ≤8 before initial resuscitation) and, on mechanical ventilation at the time of imaging are eligible. Patients will undergo CTP at the time of first imaging on their hospital admission. Admission CTP compares with the reference standard of an accepted bedside clinical assessment for brainstem function. Deferred consent will be used. The primary outcome is a binary outcome of mortality (dead) or survival (not dead) in the first 48 hours of admission. The planned sample size for achieving a sensitivity of 75% and a specificity of 95% with a CI of ±5% is 200 patients.Ethics and dissemination This study has been approved by the University of Manitoba Health Research Ethics Board. The findings from our study will be disseminated through peer-reviewed journals and presentations at local rounds, national and international conferences. The public will be informed through forums at the end of the study.Trial registration number NCT04318665