RT Journal Article
SR Electronic
T1 Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e045286
DO 10.1136/bmjopen-2020-045286
VO 11
IS 4
A1 Dambha-Miller, Hajira
A1 Tan, Pui San
A1 Saatci, Defne
A1 Clift, Ashley Kieran
A1 Zaccardi, Francesco
A1 Coupland, Carol
A1 Locufier, Patrick
A1 Davies, Firoza
A1 Khunti, Kamlesh
A1 Griffin, Simon J
A1 Hippisley-Cox, Julia
YR 2021
UL http://bmjopen.bmj.com/content/11/4/e045286.abstract
AB Introduction Recent evidence suggests that ethnic minority groups are disproportionately at increased risk of hospitalisation and death from SARS-CoV-2 infection. Population-based evidence on potential explanatory factors across minority groups and within subgroups is lacking. This study aims to quantify the association between ethnicity and the risk of hospitalisation and mortality due to COVID-19.Methods and analysis This is a retrospective cohort study of adults registered across a representative and anonymised national primary care database (QResearch) that includes data on 10 million people in England. Sociodemographic, deprivation, clinical and domicile characteristics will be summarised and compared across ethnic subgroups (categorised as per 2011 census). Cox models will be used to calculate HR for hospitalisation and COVID-19 mortality associated with ethnic group. Potential confounding and explanatory factors (such as demographic, socioeconomic and clinical) will be adjusted for within regression models. The percentage contribution of distinct risk factor classes to the excess risks seen in ethnic groups/subgroups will be calculated.Ethics and dissemination The study has undergone ethics review in accordance with the QResearch agreement (reference OX102). Findings will be disseminated through peer-reviewed manuscripts, presentations at scientific meetings and conferences with national and international stakeholders.