RT Journal Article
SR Electronic
T1 Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e040736
DO 10.1136/bmjopen-2020-040736
VO 10
IS 11
A1 Ishan Paranjpe
A1 Adam J Russak
A1 Jessica K De Freitas
A1 Anuradha Lala
A1 Riccardo Miotto
A1 Akhil Vaid
A1 Kipp W Johnson
A1 Matteo Danieletto
A1 Eddye Golden
A1 Dara Meyer
A1 Manbir Singh
A1 Sulaiman Somani
A1 Arjun Kapoor
A1 Ross O'Hagan
A1 Sayan Manna
A1 Udit Nangia
A1 Suraj K Jaladanki
A1 Paul O’Reilly
A1 Laura M Huckins
A1 Patricia Glowe
A1 Arash Kia
A1 Prem Timsina
A1 Robert M Freeman
A1 Matthew A Levin
A1 Jeffrey Jhang
A1 Adolfo Firpo
A1 Patricia Kovatch
A1 Joseph Finkelstein
A1 Judith A Aberg
A1 Emilia Bagiella
A1 Carol R Horowitz
A1 Barbara Murphy
A1 Zahi A Fayad
A1 Jagat Narula
A1 Eric J Nestler
A1 V Fuster
A1 Carlos Cordon-Cardo
A1 Dennis Charney
A1 David L Reich
A1 Allan Just
A1 Erwin P Bottinger
A1 Alexander W Charney
A1 Benjamin S Glicksberg
A1 Girish N Nadkarni
A1 ,
YR 2020
UL http://bmjopen.bmj.com/content/10/11/e040736.abstract
AB Objective The COVID-19 pandemic is a global public health crisis, with over 33 million cases and 999 000 deaths worldwide. Data are needed regarding the clinical course of hospitalised patients, particularly in the USA. We aimed to compare clinical characteristic of patients with COVID-19 who had in-hospital mortality with those who were discharged alive.Design Demographic, clinical and outcomes data for patients admitted to five Mount Sinai Health System hospitals with confirmed COVID-19 between 27 February and 2 April 2020 were identified through institutional electronic health records. We performed a retrospective comparative analysis of patients who had in-hospital mortality or were discharged alive.Setting All patients were admitted to the Mount Sinai Health System, a large quaternary care urban hospital system.Participants Participants over the age of 18 years were included.Primary outcomes We investigated in-hospital mortality during the study period.Results A total of 2199 patients with COVID-19 were hospitalised during the study period. As of 2 April, 1121 (51%) patients remained hospitalised, and 1078 (49%) completed their hospital course. Of the latter, the overall mortality was 29%, and 36% required intensive care. The median age was 65 years overall and 75 years in those who died. Pre-existing conditions were present in 65% of those who died and 46% of those discharged. In those who died, the admission median lymphocyte percentage was 11.7%, D-dimer was 2.4 μg/mL, C reactive protein was 162 mg/L and procalcitonin was 0.44 ng/mL. In those discharged, the admission median lymphocyte percentage was 16.6%, D-dimer was 0.93 μg/mL, C reactive protein was 79 mg/L and procalcitonin was 0.09 ng/mL.Conclusions In our cohort of hospitalised patients, requirement of intensive care and mortality were high. Patients who died typically had more pre-existing conditions and greater perturbations in inflammatory markers as compared with those who were discharged.