RT Journal Article
SR Electronic
T1 Evaluation of the role of sex as a prognostic factor in critically ill adults with sepsis: systematic review protocol
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e035927
DO 10.1136/bmjopen-2019-035927
VO 10
IS 5
A1 Jesus Lopez-Alcalde
A1 Alba Antequera Martín
A1 Elena Stallings
A1 Alfonso Muriel
A1 Borja Fernández-Félix
A1 Ivan Solà
A1 Rosa del Campo
A1 Manuel Ponce-Alonso
A1 Federico Gordo
A1 Pilar Fidalgo
A1 Ana Verónica Halperin
A1 Noelia Álvarez-Díaz
A1 Olaya Madrid-Pascual
A1 Gerard Urrutia
A1 Javier Zamora
YR 2020
UL http://bmjopen.bmj.com/content/10/5/e035927.abstract
AB Introduction Sepsis is a leading cause of mortality in critically ill patients. Recently, it has been recognised that sex may contribute to a differential risk for developing sepsis and it remains uncertain if the prognosis of sepsis varies between the sexes. The aim of this systematic review is to summarise the available evidence to assess the role of sex as a prognostic factor in patients with sepsis managed in the intensive care unit (ICU).Methods and analysis This is a systematic review protocol of prognostic studies of sex in patients with sepsis managed in the ICU. The primary outcomes include all-cause hospital mortality and all-cause hospital mortality during the first 28 days. The secondary outcomes include all-cause hospital mortality during the first 7 days and all-cause mortality at 1 year. We will conduct a search strategy based on the population (sepsis), the prognostic factor (sex), the outcome of interest (mortality) and prognostic study methods. We will search in the following databases up to December 2019: MEDLINE Ovid (from 1976), Embase Elsevier (from 1974), Web of Science and two trial registries. We will impose no language restrictions. Two authors will independently screen titles, abstracts and full-text articles for eligibility of studies, and subsequently extract data. Two authors will independently assess the risk of bias of each study using the Quality in Prognostic Studies (QUIPS) tool. If possible, we will carry out a meta-analysis to provide a pooled prognostic effect estimate for each outcome. We will use the Grading of Recommendations Assessment, Development and Evaluation system to assess the quality of evidence.Ethics and dissemination Ethical approval will not be required. Findings from this review will be reported in a peer-reviewed scientific journal. Additionally, the results will be disseminated at conferences and in the mass media.PROSPERO registration number CRD42019145054.