TY - JOUR T1 - Measurement challenge: protocol for international case–control comparison of mammographic measures that predict breast cancer risk JF - BMJ Open JO - BMJ Open DO - 10.1136/bmjopen-2019-031041 VL - 9 IS - 12 SP - e031041 AU - Evenda Dench AU - Daniela Bond-Smith AU - Ellie Darcey AU - Grant Lee AU - Ye K Aung AU - Ariane Chan AU - Jack Cuzick AU - Ze Y Ding AU - Chris F Evans AU - Jennifer Harvey AU - Ralph Highnam AU - Meng-Kang Hsieh AU - Despina Kontos AU - Shuai Li AU - Shivaani Mariapun AU - Carolyn Nickson AU - Tuong L Nguyen AU - Said Pertuz AU - Pietro Procopio AU - Nadia Rajaram AU - Kathy Repich AU - Maxine Tan AU - Soo-Hwang Teo AU - Nhut Ho Trinh AU - Giske Ursin AU - Chao Wang AU - Isabel dos-Santos-Silva AU - Valerie McCormack AU - Mads Nielsen AU - John Shepherd AU - John L Hopper AU - Jennifer Stone Y1 - 2019/12/01 UR - http://bmjopen.bmj.com/content/9/12/e031041.abstract N2 - Introduction For women of the same age and body mass index, increased mammographic density is one of the strongest predictors of breast cancer risk. There are multiple methods of measuring mammographic density and other features in a mammogram that could potentially be used in a screening setting to identify and target women at high risk of developing breast cancer. However, it is unclear which measurement method provides the strongest predictor of breast cancer risk.Methods and analysis The measurement challenge has been established as an international resource to offer a common set of anonymised mammogram images for measurement and analysis. To date, full field digital mammogram images and core data from 1650 cases and 1929 controls from five countries have been collated. The measurement challenge is an ongoing collaboration and we are continuing to expand the resource to include additional image sets across different populations (from contributors) and to compare additional measurement methods (by challengers). The intended use of the measurement challenge resource is for refinement and validation of new and existing mammographic measurement methods. The measurement challenge resource provides a standardised dataset of mammographic images and core data that enables investigators to directly compare methods of measuring mammographic density or other mammographic features in case/control sets of both raw and processed images, for the purposes of the comparing their predictions of breast cancer risk.Ethics and dissemination Challengers and contributors are required to enter a Research Collaboration Agreement with the University of Melbourne prior to participation in the measurement challenge. The Challenge database of collated data and images are stored in a secure data repository at the University of Melbourne. Ethics approval for the measurement challenge is held at University of Melbourne (HREC ID 0931343.3). ER -