RT Journal Article
SR Electronic
T1 Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture: a substudy protocol of the hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) international randomised controlled trial
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e033150
DO 10.1136/bmjopen-2019-033150
VO 9
IS 9
A1 Flavia K Borges
A1 P J Devereaux
A1 Meaghan Cuerden
A1 Mohit Bhandari
A1 Ernesto Guerra-Farfán
A1 Ameen Patel
A1 Alben Sigamani
A1 Masood Umer
A1 John Neary
A1 Maria Tiboni
A1 Vikas Tandon
A1 Mmampapatla Thomas Ramokgopa
A1 Parag Sancheti
A1 Bobby John
A1 AbdelRahman Lawendy
A1 Mariano Balaguer-Castro
A1 Richard Jenkinson
A1 Paweł Ślęczka
A1 Aamer Nabi Nur
A1 Gavin C A Wood
A1 Robert Feibel
A1 John Stephen McMahon
A1 Alen Sigamani
A1 Bruce M Biccard
A1 Giovanni Landoni
A1 Wojciech Szczeklik
A1 Chew Yin Wang
A1 Jordi Tomas-Hernandez
A1 Valsa Abraham
A1 Jessica Vincent
A1 Valerie Harvey
A1 Shirley Pettit
A1 Jessica Sontrop
A1 Amit X Garg
A1 ,
YR 2019
UL http://bmjopen.bmj.com/content/9/9/e033150.abstract
AB Introduction Inflammation, dehydration, hypotension and bleeding may all contribute to the development of acute kidney injury (AKI). Accelerated surgery after a hip fracture can decrease the exposure time to such contributors and may reduce the risk of AKI.Methods and analysis Hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) is a multicentre, international, parallel-group randomised controlled trial (RCT). Patients who suffer a hip fracture are randomly allocated to either accelerated medical assessment and surgical repair with a goal of surgery within 6 hours of diagnosis or standard care where a repair typically occurs 24 to 48 hours after diagnosis. The primary outcome of this substudy is the development of AKI within 7 days of randomisation. We anticipate at least 1998 patients will participate in this substudy.Ethics and dissemination We obtained ethics approval for additional serum creatinine recordings in consecutive patients enrolled at 70 participating centres. All patients provide consent before randomisation. We anticipate reporting substudy results by 2021.Trial registration number NCT02027896; Pre-results.