RT Journal Article
SR Electronic
T1 Evaluating the endometabolic and bone health effects of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukaemia: a systematic review protocol
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e030092
DO 10.1136/bmjopen-2019-030092
VO 9
IS 9
A1 Janatani Balakumaran
A1 Tanisha Birk
A1 Breanne Golemiec
A1 Wryan Helmeczi
A1 Jeyanth Inkaran
A1 Yun-ya Kao
A1 Jennifer Leigh
A1 Sarah Saliba
A1 Rishi Sharma
A1 Laura Spatafora
A1 Kristin Wright
A1 William Yao
A1 Christopher Hillis
A1 Laura Banfield
A1 Lehana Thabane
A1 Uma Athale
A1 M Constantine Samaan
YR 2019
UL http://bmjopen.bmj.com/content/9/9/e030092.abstract
AB Introduction Chronic Myeloid Leukaemia (CML) constitutes 15% of new adult leukaemia cases as well as 2%–3% of leukaemia in children under 15% and 9% of leukaemias in adolescents 15–19 years of age annually. The introduction of Tyrosine Kinase Inhibitors (TKI) therapy has dramatically improved survival in these patients, yet the off-target effects of this treatment may have long-term health impacts on CML survivors. The risk of adverse health outcomes is especially important in children, where TKI exposure may occur during critical windows of growth and puberty, and patients require treatment for prolonged periods of time. The aim of this systematic review protocol is to report on the methods used to conduct a systematic review to investigate the endometabolic and bone health effects of TKI therapy in CML.Methods and analysis Searches will be conducted in the Cochrane Central Register of Controlled Trials, EMBASE and MEDLINE from inception on August 1st, 2019. Searches may be updated while performing the systematic review to ensure new evidence is included if applicable. Grey literature search will include ClinicalTrials.gov and ProQuest Dissertations and Theses A&I. We will perform a meta-analysis if there are at least two studies reporting similar populations, interventions, methods and tracking the same outcome measures. The studies should also have similar age and sex distributions.Ethics and dissemination As this is a systematic review protocol, it does not include patient data; therefore, Research Ethics Board approval is not indicated. The systematic review will be published in a peer-reviewed journal and presented at international conferences.PROSPERO registration number CRD42018091175.