PT  - JOURNAL ARTICLE
AU  - Laura Birch
AU  - Rachel Perry
AU  - Linda P Hunt
AU  - Rhys Matson
AU  - Amanda Chong
AU  - Rhona Beynon
AU  - Julian PH Shield
TI  - What change in body mass index is associated with improvement in percentage body fat in childhood obesity? A meta-regression
AID  - 10.1136/bmjopen-2018-028231
DP  - 2019 Aug 01
TA  - BMJ Open
PG  - e028231
VI  - 9
IP  - 8
4099  - http://bmjopen.bmj.com/content/9/8/e028231.short
4100  - http://bmjopen.bmj.com/content/9/8/e028231.full
SO  - BMJ Open2019 Aug 01; 9
AB  - Objective Using meta-regression this paper sets out the minimum change in body mass index-SD score (BMI-SDS) required to improve adiposity as percentage body fat for children and adolescents with obesity.Design Meta-regression.Setting Studies were identified as part of a large-scale systematic review of the following electronic databases: AMED, Embase, MEDLINE via OVID, Web of Science and CENTRAL via Cochrane library.Participants Individuals aged 4–19 years with a diagnosis of obesity according to defined BMI thresholds.Interventions Studies of lifestyle treatment interventions that included dietary, physical activity and/or behavioural components with the objective of reducing obesity were included. Interventions of <2 weeks duration and those that involved surgical and/or pharmacological components (eg, bariatric surgery, drug therapy) were excluded.Primary and secondary outcome measures To be included in the review, studies had to report baseline and post-intervention BMI-SDS or change measurements (primary outcome measures) plus one or more of the following markers of metabolic health (secondary outcome measures): adiposity measures other than BMI; blood pressure; glucose; inflammation; insulin sensitivity/resistance; lipid profile; liver function. This paper focuses on adiposity measures only. Further papers in this series will report on other outcome measures.Results This paper explores the potential impact of BMI-SDS reduction in terms of change in percentage body fat. Thirty-nine studies reporting change in mean percentage body fat were analysed. Meta-regression demonstrated that reduction of at least 0.6 in mean BMI-SDS ensured a mean reduction of percentage body fat mass, in the sense that the associated 95% prediction interval for change in mean percentage body fat was wholly negative.Conclusions Interventions demonstrating reductions of 0.6 BMI-SDS might be termed successful in reducing adiposity, a key purpose of weight management interventions.Trial registration number CRD42016025317.