RT Journal Article
SR Electronic
T1 High prevalence of hyperuricaemia and its impact on non-valvular atrial fibrillation: the cross-sectional Guangzhou (China) Heart Study
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e028007
DO 10.1136/bmjopen-2018-028007
VO 9
IS 5
A1 Wei-dong Lin
A1 Hai Deng
A1 Pi Guo
A1 Fang-zhou Liu
A1 Ru-yin Chen
A1 Xian-hong Fang
A1 Xian-zhang Zhan
A1 Hong-tao Liao
A1 Wen-xiang Huang
A1 Yang Liu
A1 Feng Wang
A1 Mu-rui Zheng
A1 Hua-zhang Liu
A1 Jun Huang
A1 Wei Wei
A1 Yu-mei Xue
A1 Shu-lin Wu
YR 2019
UL http://bmjopen.bmj.com/content/9/5/e028007.abstract
AB Objectives There are country and regional variations in the prevalence of hyperuricaemia (HUA). The prevalence of HUA and non-valvular atrial fibrillation (NVAF) in southern China is unknown.Design A cross-sectional study.Setting and participants A total of 11 488 permanent residents aged 35 or older from urban and rural areas of Guangzhou, China were enrolled. A questionnaire was used to compile each participant’s demographic information and relevant epidemiological factors for HUA and NVAF. All participants were assessed using a panel of blood tests and single-lead 24-hour ECG.Main outcome measures HUA was defined as serum uric acid level >420 μmol/L in men and >360 μmol/L in women. NVAF was diagnosed as per guidelines.Results The prevalence of HUA was 39.6% (44.8% in men and 36.7% in women), and 144 residents (1.25%) had NVAF. Prevalence of HUA increased with age in women but remained stably high in men. After adjusting for potential confounders, age, living in urban areas, alcohol consumption, central obesity, elevated fasting plasma glucose level, elevated blood pressure, lower high-density lipoprotein cholesterol level and elevated triglycerides level were associated with increased risk of HUA. Residents with HUA were at higher risk for NVAF. Serum uric acid level had a modest predictive value for NVAF in women but not men.Conclusions HUA was highly prevalent among citizens of southern China and was a predictor of NVAF among women.