TY - JOUR T1 - Prescribing practice of pregabalin/gabapentin in pain therapy: an evaluation of German claim data JF - BMJ Open JO - BMJ Open DO - 10.1136/bmjopen-2018-021535 VL - 9 IS - 3 SP - e021535 AU - Annika Viniol AU - Tina Ploner AU - Lennart Hickstein AU - Jörg Haasenritter AU - Karl Martin Klein AU - Jochen Walker AU - Norbert Donner-Banzhoff AU - Annette Becker Y1 - 2019/03/01 UR - http://bmjopen.bmj.com/content/9/3/e021535.abstract N2 - Objectives To analyse the prevalence and incidence of pregabalin and gabapentin (P/G) prescriptions, typical therapeutic uses of P/G with special attention to pain-related diagnoses and discontinuation rates.Design Secondary data analysis.Setting Primary and secondary care in Germany.Participants Four million patients in the years 2009–2015 (anonymous health insurance data).Intervention None.Primary and secondary outcome measures P/G prescribing rates, P/G prescribing rates associated with pain therapy, analysis of pain-related diagnoses leading to new P/G prescriptions and the discontinuation rate of P/G.Results In 2015, 1.6% of insured persons received P/G prescriptions. Among the patients with pain first treated with P/G, as few as 25.7% were diagnosed with a typical neuropathic pain disorder. The remaining 74.3% had either not received a diagnosis of neuropathic pain or showed a neuropathic component that was pathophysiologically conceivable but did not support the prescription of P/G. High discontinuation rates were observed (85%). Among the patients who had discontinued the drug, 61.1% did not receive follow-up prescriptions within 2 years.Conclusion The results show that P/G is widely prescribed in cases of chronic pain irrespective of neuropathic pain diagnoses. The high discontinuation rate indicates a lack of therapeutic benefits and/or the occurrence of adverse effects. ER -