RT Journal Article SR Electronic T1 Protocol for a quasi-experimental study of the effectiveness and cost-effectiveness of mother and baby units compared with general psychiatric inpatient wards and crisis resolution team services (The ESMI study) in the provision of care for women in the postpartum period JF BMJ Open JO BMJ Open FD British Medical Journal Publishing Group SP e025906 DO 10.1136/bmjopen-2018-025906 VO 9 IS 3 A1 Kylee Trevillion A1 Rebekah Shallcross A1 Elizabeth Ryan A1 Margaret Heslin A1 Andrew Pickles A1 Sarah Byford A1 Ian Jones A1 Sonia Johnson A1 Susan Pawlby A1 Nicky Stanley A1 Diana Rose A1 Gertrude Seneviratne A1 Angelika Wieck A1 Stacey Jennings A1 Laura Potts A1 Kathryn M Abel A1 Louise M Howard YR 2019 UL http://bmjopen.bmj.com/content/9/3/e025906.abstract AB Introduction Research into what constitutes the best and most effective care for women with an acute severe postpartum mental disorder is lacking. The effectiveness and cost-effectiveness of psychiatric mother and baby units (MBUs) has not been investigated systematically and there has been no direct comparison of the outcomes of mothers and infants admitted to these units, compared with those accessing generic acute psychiatric wards or crisis resolution teams (CRTs). Our primary hypothesis is that women with an acute psychiatric disorder, in the first year after giving birth, admitted to MBUs are significantly less likely to be readmitted to acute care (an MBU, CRTs or generic acute ward) in the year following discharge than women admitted to generic acute wards or cared for by CRTs.Methods and analysis Quasi-experimental study of women accessing different types of acute psychiatric services in the first year after childbirth. Analysis of the primary outcome will be compared across the three service types, at 1-year postdischarge. Cost-effectiveness will be compared across the three service types, at 1-month and 1-year postdischarge; explored in terms of quality-adjusted life years. Secondary outcomes include unmet needs, service satisfaction, maternal adjustment, quality of mother–infant interaction. Outcomes will be analysed using propensity scoring to account for systematic differences between MBU and non-MBU participants. Analyses will take place separately within strata, defined by the propensity score, and estimates pooled to produce an average treatment effect with weights to account for cohort attrition.Ethics and dissemination The study has National Health Service (NHS) Ethics Approval and NHS Trust Research and Development approvals. The study has produced protocols on safeguarding maternal/child welfare. With input from our lived experience group, we have developed a dissemination strategy for academics/policy-makers/public.