RT Journal Article SR Electronic T1 Community ageing research 75+ study (CARE75+): an experimental ageing and frailty research cohort JF BMJ Open JO BMJ Open FD British Medical Journal Publishing Group SP e026744 DO 10.1136/bmjopen-2018-026744 VO 9 IS 3 A1 Anne Heaven A1 Lesley Brown A1 John Young A1 Elizabeth Teale A1 Rebecca Hawkins A1 Karen Spilsbury A1 Gail Mountain A1 Tracey Young A1 Victoria Goodwin A1 Barbara Hanratty A1 Carolyn Chew-Graham A1 Caroline Brundle A1 Farhat Mahmood A1 Ikhlaq Jacob A1 Amrit Daffu-O’Reilly A1 Andrew Clegg YR 2019 UL http://bmjopen.bmj.com/content/9/3/e026744.abstract AB Introduction The Community Ageing Research 75+ Study (CARE75+) is a longitudinal cohort study collecting an extensive range of health, social and economic data, with a focus on frailty, independence and quality of life in older age. CARE75+ is the first international experimental frailty research cohort designed using Trial within Cohorts (TwiCs) methodology, to align applied epidemiological research with clinical trial evaluation of interventions to improve the health and well-being of older people living with frailty.Methods and analysis Prospective cohort study using a TwiCs design. One thousand community-dwelling older people (≥75 years) will be recruited from UK general practices. Nursing home residents, those with an estimated life expectancy of 3 months or less and people receiving palliative care will be excluded. Data collection assessments will be face to face in the person’s home at baseline, 6 months, 12 months, 24 months and 48 months, including assessments of frailty, cognition, mood, health-related quality of life, comorbidity, medications, resilience, loneliness, pain and self-efficacy. A modified protocol for follow-up by telephone or web based will be offered at 6 months. Consent will be sought for data linkage and invitations to additional studies, including intervention studies using the TwiCs design. A blood sample biobank will be established for future basic science studies.Ethics and dissemination CARE75+ was approved by the NRES Committee Yorkshire and the Humber—Bradford Leeds 10 October 2014 (14/YH/1120). Formal written consent is sought if an individual is willing to participate and has capacity to provide informed consent. Consultee assent is sought if an individual lacks capacity.Study results will be disseminated in peer-reviewed scientific journals and scientific conferences. Key study results will be summarised and disseminated to all study participants via newsletters, local older people’s publications and local engagement events. Results will be reported on a bespoke CARE75+ website.Trial registration number ISRCTN16588124;Results stage