RT Journal Article
SR Electronic
T1 Examination of psychological risk factors for chronic pain following cardiac surgery: protocol for a prospective observational study
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e022995
DO 10.1136/bmjopen-2018-022995
VO 9
IS 2
A1 Michael H McGillion
A1 Shaunattonie Henry
A1 Jason W Busse
A1 Carley Ouellette
A1 Joel Katz
A1 Manon Choinière
A1 Andre Lamy
A1 Richard Whitlock
A1 Shirley Pettit
A1 Jacqueline Hare
A1 Krysten Gregus
A1 Katheryn Brady
A1 Nazari Dvirnik
A1 Stephen Su Yang
A1 Joel Parlow
A1 Deborah Dumerton-Shore
A1 Ian Gilron
A1 D Norman Buckley
A1 Harsha Shanthanna
A1 Sandra L Carroll
A1 Peter C Coyte
A1 Shanil Ebrahim
A1 Wanrudee Isaranuwatchai
A1 Denise N Guerriere
A1 Jeffrey Hoch
A1 James Khan
A1 Joy MacDermid
A1 Geraldine Martorella
A1 J Charles Victor
A1 Judy Watt-Watson
A1 Kimberly Howard-Quijano
A1 Aman Mahajan
A1 Matthew T V Chan
A1 Hance Clarke
A1 P J Devereaux
YR 2019
UL http://bmjopen.bmj.com/content/9/2/e022995.abstract
AB Introduction Approximately 400 000 Americans and 36 000 Canadians undergo cardiac surgery annually, and up to 56% will develop chronic postsurgical pain (CPSP). The primary aim of this study is to explore the association of pain-related beliefs and gender-based pain expectations on the development of CPSP. Secondary goals are to: (A) explore risk factors for poor functional status and patient-level cost of illness from a societal perspective up to 12 months following cardiac surgery; and (B) determine the impact of CPSP on quality-adjusted life years (QALYs) borne by cardiac surgery, in addition to the incremental cost for one additional QALY gained, among those who develop CPSP compared with those who do not.Methods and analyses In this prospective cohort study, 1250 adults undergoing cardiac surgery, including coronary artery bypass grafting and open-heart procedures, will be recruited over a 3-year period. Putative risk factors for CPSP will be captured prior to surgery, at postoperative day 3 (in hospital) and day 30 (at home). Outcome data will be collected via telephone interview at 6-month and 12-month follow-up. We will employ generalised estimating equations to model the primary (CPSP) and secondary outcomes (function and cost) while adjusting for prespecified model covariates. QALYs will be estimated by converting data from the Short Form-12 (version 2) to a utility score.Ethics and dissemination This protocol has been approved by the responsible bodies at each of the hospital sites, and study enrolment began May 2015. We will disseminate our results through CardiacPain.Net, a web-based knowledge dissemination platform, presentation at international conferences and publications in scientific journals.Trial registration number NCT01842568.