PT  - JOURNAL ARTICLE
AU  - Noushin Fahimfar
AU  - Davood Khalili
AU  - Sadaf Ghajarieh Sepanlou
AU  - Reza Malekzadeh
AU  - Fereidoun Azizi
AU  - Mohammad Ali Mansournia
AU  - Hamidreza Roohafza
AU  - Mohammad Hassan Emamian
AU  - Farzad Hadaegh
AU  - Hossein Poustchi
AU  - Marjan Mansourian
AU  - Hassan Hashemi
AU  - Maryam Sharafkhah
AU  - Akram Pourshams
AU  - Farshad Farzadfar
AU  - Ewout W Steyerberg
AU  - Akbar Fotouhi
TI  - Cardiovascular mortality in a Western Asian country: results from the Iran Cohort Consortium
AID  - 10.1136/bmjopen-2017-020303
DP  - 2018 Jul 01
TA  - BMJ Open
PG  - e020303
VI  - 8
IP  - 7
4099  - http://bmjopen.bmj.com/content/8/7/e020303.short
4100  - http://bmjopen.bmj.com/content/8/7/e020303.full
SO  - BMJ Open2018 Jul 01; 8
AB  - Objectives Cardiovascular mortality in Western Asia is high and still rising. However, most data documented on risk prediction has been derived from Western countries and few population-based cohort studies have been conducted in this region. The current study aimed to present the process of pooling data and cardiovascular disease (CVD) mortality incidences for four Iranian cohorts.Methods From the Iran Cohort Consortium, the Golestan Cohort Study (GCS), Tehran Lipid and Glucose Study, Isfahan Cohort Study (ICS) and the Shahroud Eye Cohort Study (ShECS) were eligible for the current study since they had appropriate data and follow-up visits. Age-standardised CVD mortality rates were estimated for ages 40–80 and 40–65 years. Cox regression was used to compare mortalities among cohorts. Adjusted marginal rates were calculated using Poisson regression.Results Overall, 61 291 participants (34 880 women) aged 40–80 years, free of CVD at baseline, were included. During 504 606 person-years of follow-up, 1981 CVD deaths (885 women) occurred. Age-standardised/sex-standardised premature CVD mortality rates were estimated from 133 per 100 000 person-years (95% CI 81 to 184) in ShECS to 366 (95% CI 342 to 389) in the GCS. Compared with urban women, rural women had higher CVD mortality in the GCS but not in the ICS. The GCS population had a higher risk of CVD mortality, compared with the others, adjusted for conventional CVD risk factors.Conclusions The incidence of CVD mortality is high with some differences between urban and rural cohorts in Iran as a Western Asian country. Pooling data facilitates the opportunity to globally evaluate risk prediction models.