RT Journal Article
SR Electronic
T1 POP-Brazil study protocol: a nationwide cross-sectional evaluation of the prevalence and genotype distribution of human papillomavirus (HPV) in Brazil
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e021170
DO 10.1136/bmjopen-2017-021170
VO 8
IS 6
A1 Eliana Marcia Wendland
A1 Juliana Caierão
A1 Carla Domingues
A1 Ana Goretti Kalume Maranhão
A1 Flávia Moreno Alves de Souza
A1 Luciano Serpa Hammes
A1 Maicon Falavigna
A1 Juliana Balbinot Hilgert
A1 Fernando Neves Hugo
A1 Marina Bessel
A1 Luisa Lina Villa
A1 Adele Schwartz Benzaken
YR 2018
UL http://bmjopen.bmj.com/content/8/6/e021170.abstract
AB Introduction Human papillomavirus (HPV) is associated with the development of genital warts and different types of cancer, including virtually all cervical cancers and a considerable number of penile, anal and oropharyngeal cancers. Data regarding the prevalence of HPV infection in Brazil are limited and fragmented. We aim to determine HPV prevalence in sexually active women and men aged 16–25 years and to investigate regional differences in virus prevalence and types.Methods and analysis This is a nationwide, multicentric, cross-sectional, prospective study that will include participants aged 16–25 years from all Brazilian capital cities. Recruitment will occur in primary health units by trained health professionals who will be responsible for collecting biological samples and interviewing the volunteers. After signing informed consent, all participants will answer a questionnaire that will collect sociodemographic and behavioural data. All samples will be processed in a certified central laboratory, and strict quality control will be performed by many different procedures, including double data entry, training and certification of primary care health professionals responsible for data collection, simulation of interviews, and auditing and monitoring of visits. The sample size will be standardised based on the population distribution of each capital using SAS and R statistical software.Ethics and dissemination The project was approved by the research ethics committee of the main institution and the corresponding ethics committees of the recruitment sites. This will be the first Brazilian nationwide study to determine overall HPV prevalence and to examine regional differences and social, demographic and behavioural factors related to HPV infection. Critical analysis of the study results will contribute to epidemiological knowledge and will set a baseline for future evaluation of the impact of the National HPV Vaccination Program.